| IED ID | IndEnz0002008924 |
| Enzyme Type ID | protease008924 |
| Protein Name |
Carboxypeptidase S1 homolog B EC 3.4.16.6 Serine carboxypeptidase B SPCB |
| Gene Name | SCPB |
| Organism | Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum) |
| Enzyme Sequence | MVSFCGVAACLLTVAGHLAQAQFPPKPEGVTVLESKFGSGARITYKEPGLCETTEGVKSYAGYVHLPPGTLRDFGVEQDYPINTFFWFFEARKDPENAPLGIWMNGGPGSSSMFGMMTENGPCFVNADSNSTRLNPHSWNNEVNMLYIDQPVQVGLSYDTLANFTRNLVTDEITKLKPGEPIPEQNATFLVGTYASRNMNTTAHGTRHAAMALWHFAQVWFQEFPGYHPRNNKISIATESYGGRYGPAFTAFFEEQNQKIKNGTWKGHEGTMHVLHLDTLMIVNGCIDRLVQWPAYPQMAYNNTYSIEAVNASIHAGMLDALYRDGGCRDKINHCRSLSSVFDPENLGINSTVNDVCKDAETFCSNDVRDPYLKFSGRNYYDIGQLDPSPFPAPFYMAWLNQPHVQAALGVPLNWTQSNDVVSTAFRAIGDYPRPGWLENLAYLLENGIKVSLVYGDRDYACNWFGGELSSLGINYTDTHEFHNAGYAGIQINSSYIGGQVRQYGNLSFARVYEAGHEVPSYQPETALQIFHRSLFNKDIATGTKDTSSRMDGGKFYGTSGPADSFGFKNKPPPQHVHFCHILDTSTCTKEQIQSVENGTAAVRSWIIVDSNSTSLFPEVVGSGEPTPTPMPGGATTLSAHGFLYGVTLWAVIVVAVIELAM |
| Enzyme Length | 662 |
| Uniprot Accession Number | Q5J6J2 |
| Absorption | |
| Active Site | ACT_SITE 240; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 459; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 517; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074 |
| Activity Regulation | |
| Binding Site | BINDING 462; /note=Substrate; /evidence=ECO:0000250; BINDING 518; /note=Substrate; /evidence=ECO:0000250 |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential release of a C-terminal arginine or lysine residue.; EC=3.4.16.6; |
| DNA Binding | |
| EC Number | 3.4.16.6 |
| Enzyme Function | FUNCTION: Extracellular serine carboxypeptidase that contributes to pathogenicity. {ECO:0000269|PubMed:18222721}. |
| Temperature Dependency | |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 8.0. {ECO:0000269|PubMed:18222721}; |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Binding site (2); Chain (1); Disulfide bond (3); Glycosylation (14); Lipidation (1); Propeptide (1); Signal peptide (1) |
| Keywords | Carboxypeptidase;Cell membrane;Disulfide bond;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Signal;Virulence |
| Interact With | |
| Induction | INDUCTION: Expression is strongly increased during growth on protein-rich medium. {ECO:0000269|PubMed:19098130}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 73,012 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |