| IED ID |
IndEnz0002008972 |
| Enzyme Type ID |
protease008972 |
| Protein Name |
Sodium-dependent dopamine transporter
DA transporter
DAT
Solute carrier family 6 member 3
|
| Gene Name |
Slc6a3 Dat Dat1 |
| Organism |
Mus musculus (Mouse) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Myomorpha (mice and others)
Muroidea
Muridae
Murinae
Mus
Mus
Mus musculus (Mouse)
|
| Enzyme Sequence |
MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDRQLVDRGEVRQFTLRHWLLV |
| Enzyme Length |
619 |
| Uniprot Accession Number |
Q61327 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Amine transporter (PubMed:10375632, PubMed:12606774). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (PubMed:30936473). {ECO:0000250|UniProtKB:P23977, ECO:0000269|PubMed:10375632, ECO:0000269|PubMed:12606774, ECO:0000269|PubMed:30936473}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (2); Glycosylation (4); Metal binding (9); Mutagenesis (4); Region (1); Site (1); Topological domain (3); Transmembrane (12) |
| Keywords |
Cell membrane;Cell projection;Disulfide bond;Glycoprotein;Membrane;Metal-binding;Neurotransmitter transport;Reference proteome;Sodium;Symport;Transmembrane;Transmembrane helix;Transport |
| Interact With |
O55042; P37840 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10375632, ECO:0000269|PubMed:12606774}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7K4Y6}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon {ECO:0000269|PubMed:17296554}. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (PubMed:17296554). {ECO:0000250|UniProtKB:P23977, ECO:0000269|PubMed:17296554}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10072302;
10195128;
10404198;
10564358;
10617152;
10637574;
10651856;
10677550;
10792459;
10915639;
10971639;
10998124;
11150348;
11172062;
11312315;
11320258;
11343649;
11404425;
11506886;
11572967;
11784783;
11803442;
12006604;
12044470;
12099912;
12193195;
12401330;
12480184;
12586455;
12617953;
12655306;
12699766;
12764108;
12958210;
14561867;
14593425;
14622207;
14681479;
14684259;
14691264;
14973278;
14980210;
15136721;
15245485;
15354185;
15447669;
15492001;
15542711;
15572278;
15584907;
15710042;
15719221;
15748955;
15763133;
15856082;
15911120;
16024787;
16050778;
16051150;
16125675;
16141072;
16339193;
16364897;
16423542;
16436185;
16525059;
16602821;
16638624;
16643512;
16675138;
16754872;
16765459;
16848782;
16865686;
16950153;
16954211;
16968817;
17000016;
17010993;
17035544;
17046697;
17065224;
17065462;
17159989;
17227870;
17250681;
17251429;
17255472;
17298183;
17408864;
17433376;
17452640;
17522168;
17584943;
17664021;
17687036;
17761882;
18056810;
18184785;
18197357;
18347339;
18363853;
18470912;
18495356;
18510945;
18596615;
18671743;
18701073;
18790059;
18799693;
18929645;
18953410;
19109492;
19142237;
19144721;
19176817;
19299613;
19339600;
19381303;
19439492;
19482066;
19515692;
19520064;
19553461;
19576892;
19615345;
19619134;
19666516;
19729052;
19750226;
19750538;
19766189;
19780901;
19842188;
19906957;
19932884;
20002202;
20016108;
20018672;
20023653;
20062537;
20093142;
20167208;
20223200;
20382201;
20386724;
20451634;
20457670;
20551317;
20558209;
20610757;
20616081;
20634895;
20656029;
20720111;
20738906;
20858707;
20976142;
20980993;
21057506;
21060884;
21092858;
21144620;
21148012;
21209835;
21233488;
21267068;
21270893;
21296093;
21368124;
21399631;
21421642;
21432587;
21439946;
21499253;
21525407;
21677750;
21743470;
21768369;
21795541;
21813695;
21880899;
21880920;
21900559;
21983691;
21990355;
22034972;
22034973;
22069189;
22090423;
22114279;
22118191;
22131425;
22143804;
22163275;
22196339;
22238104;
22251459;
22258508;
22267337;
22278924;
22330100;
22393477;
22434189;
22483304;
22537018;
22542182;
22564125;
22572477;
22712725;
22748019;
22778257;
22781838;
22809709;
22841315;
22859504;
22875923;
22914740;
22961549;
23034651;
23042896;
23083326;
23100428;
23152632;
23197738;
23217170;
23240026;
23264561;
23305992;
23458603;
23481388;
23534961;
23558143;
23637192;
23681253;
23817546;
23817550;
23863478;
23884410;
23921954;
23933217;
23959937;
23977020;
23978383;
24098148;
24133278;
24150248;
24155314;
24194600;
24332984;
24348261;
24486705;
24497577;
24550305;
24673634;
24742619;
24776686;
24790206;
24799694;
24802380;
24811384;
24843012;
24886986;
24952961;
24979798;
25005251;
25063810;
25068655;
25071457;
25091505;
25171792;
25258080;
25331903;
25339743;
25447236;
25505322;
25609609;
25611513;
25611514;
25714923;
25752644;
25762688;
25782435;
25817859;
25915474;
25918399;
25936602;
25948263;
26056851;
26080439;
26086365;
26139373;
26164566;
26182419;
26203861;
26207352;
26232228;
26278050;
26287463;
26321632;
26335381;
26341832;
26359992;
26364547;
26365765;
26377476;
26402461;
26407721;
26430123;
26464985;
26551563;
26565913;
26681446;
26699459;
26871628;
26879466;
26904943;
26912775;
26929359;
26961958;
27003179;
27036891;
27038906;
27053209;
27079169;
27124299;
27124386;
27163179;
27181061;
27246266;
27273769;
27292633;
27317935;
27346361;
27407143;
27408780;
27467571;
27468917;
27568516;
27581458;
27618675;
27618677;
27626380;
27647894;
27659966;
27681312;
27703142;
27716510;
27733819;
27760002;
27886263;
27889578;
27930324;
27966077;
27974817;
27976722;
28009292;
28038352;
28054919;
28072417;
28103482;
28132830;
28133444;
28174244;
28192395;
28194005;
28228269;
28244870;
28283558;
28285820;
28297663;
28297715;
28334611;
28375739;
28376279;
28394253;
28454982;
28461218;
28462393;
28466093;
28535798;
28595911;
28669546;
28714952;
28781050;
28821671;
28855580;
28894175;
28905875;
28923595;
28938472;
28941296;
28963257;
28964912;
29030221;
29030431;
29038581;
29163030;
29167404;
29177188;
29180115;
29241537;
29251597;
29256865;
29304042;
29321139;
29337309;
29355693;
29398114;
29420469;
29527566;
29615705;
29621487;
29656872;
29656874;
29676260;
29676731;
29739866;
29754751;
29760401;
29791835;
29802391;
29949769;
29958943;
30007419;
30057204;
30093665;
30100256;
30104732;
30146163;
30177795;
30210305;
30228121;
30245012;
30292429;
30295607;
30297767;
30318411;
30323275;
30344040;
30367968;
30373717;
30440089;
30442663;
30503173;
30522820;
30539268;
30540946;
30556810;
30568192;
30578419;
30590105;
30605672;
30623173;
30635563;
30664247;
30689541;
30705619;
30718039;
30718509;
30726725;
30736837;
30804529;
30837265;
30920369;
30930745;
30933310;
30970251;
31003725;
31091455;
31094705;
31097625;
31109961;
31144295;
31175277;
31189104;
31202540;
31204082;
31209151;
31226324;
31277924;
31324539;
31348890;
31361457;
31365862;
31449520;
31481399;
31486769;
31505196;
31537790;
31548368;
31596232;
31604921;
31610370;
31619451;
31644913;
31648898;
31665630;
31704785;
31750563;
31826983;
31835787;
31872525;
31890743;
31923430;
31953402;
31954621;
31974110;
32005751;
32005765;
32027824;
32027825;
32048995;
32075716;
32075770;
32132171;
32142670;
32191871;
32192190;
32214250;
32244769;
32259476;
32294466;
32317389;
32415886;
32468214;
32470362;
32490813;
32499648;
32535402;
32561725;
32564285;
32576620;
32576854;
32579581;
32579938;
32581380;
32581704;
32588892;
32640184;
32651365;
32747789;
32847967;
32859717;
32901079;
32923630;
32928885;
32961129;
32966778;
32971195;
32989293;
33046554;
33153031;
33234607;
33340529;
33345774;
33483429;
33526942;
33536201;
33558587;
33577882;
33599293;
33600762;
33861952;
33932356;
33972988;
33979604;
33979635;
34028352;
34095148;
34112787;
34145364;
34362914;
34388372;
34400288;
34516792;
34580198;
8180472;
8628395;
8903735;
8942444;
9037545;
9247269;
9482784;
9520487;
9634552;
9636213;
9888856;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
68,805 |
| Kinetics |
|
| Metal Binding |
METAL 75; /note=Sodium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q7K4Y6; METAL 77; /note=Sodium 2; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q7K4Y6; METAL 78; /note=Sodium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q7K4Y6; METAL 82; /note=Sodium 2; /evidence=ECO:0000250|UniProtKB:Q7K4Y6; METAL 320; /note=Sodium 2; /evidence=ECO:0000250|UniProtKB:Q7K4Y6; METAL 352; /note=Sodium 2; /evidence=ECO:0000250|UniProtKB:Q7K4Y6; METAL 417; /note=Sodium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q7K4Y6; METAL 420; /note=Sodium 1; /evidence=ECO:0000250|UniProtKB:Q7K4Y6; METAL 421; /note=Sodium 1; /evidence=ECO:0000250|UniProtKB:Q7K4Y6 |
| Rhea ID |
|
| Cross Reference Brenda |
|