| IED ID | IndEnz0002009024 |
| Enzyme Type ID | protease009024 |
| Protein Name |
Serine protease SplA EC 3.4.21.- |
| Gene Name | splA SACOL1869 |
| Organism | Staphylococcus aureus (strain COL) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus aureus Staphylococcus aureus (strain COL) |
| Enzyme Sequence | MNKNVMVKGLTALTILTILTSLGFAENISNQPHSIAKAEKNVKEITDATKEPYNSVVAFVGGTGVVVGKNTIVTNKHIAKSNDIFKNRVSAHHSSKGKGGGNYDVKDIVEYPGKEDLAIVHVHETSTEGLNFNKNVSYTKFADGAKVKDRISVIGYPKGAQTKYKMFESTGTINHISGTFMEFDAYAQPGNSGSPVLNSKHELIGILYAGSGKDESEKNFGVYFTPQLKEFIQNNIEK |
| Enzyme Length | 238 |
| Uniprot Accession Number | Q5HEW0 |
| Absorption | |
| Active Site | ACT_SITE 77; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 116; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 192; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Signal peptide (1) |
| Keywords | Hydrolase;Protease;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | INDUCTION: Negatively regulated by sigma-B factor. {ECO:0000269|PubMed:11681202}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..38; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 25,876 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |