| IED ID |
IndEnz0002009093 |
| Enzyme Type ID |
protease009093 |
| Protein Name |
Cell division inhibitor SulA
|
| Gene Name |
sulA sfiA b0958 JW0941 |
| Organism |
Escherichia coli (strain K12) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Gammaproteobacteria
Enterobacterales
Enterobacteriaceae
Escherichia
Escherichia coli
Escherichia coli (strain K12)
|
| Enzyme Sequence |
MYTSGYAHRSSSFSSAASKIARVSTENTTAGLISEVVYREDQPMMTQLLLLPLLQQLGQQSRWQLWLTPQQKLSREWVQASGLPLTKVMQISQLSPCHTVESMVRALRTGNYSVVIGWLADDLTEEEHAELVDAANEGNAMGFIMRPVSASSHATRQLSGLKIHSNLYH |
| Enzyme Length |
169 |
| Uniprot Accession Number |
P0AFZ5 |
| Absorption |
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| Active Site |
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| Activity Regulation |
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| Binding Site |
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| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
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| EC Number |
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| Enzyme Function |
FUNCTION: Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. The effect of overexpression of SulA is neutralized by antitoxin CbeA (yeeU) (PubMed:22515815). {ECO:0000269|PubMed:10931335, ECO:0000269|PubMed:18245292, ECO:0000269|PubMed:2145263, ECO:0000269|PubMed:22515815, ECO:0000269|PubMed:6087326, ECO:0000269|PubMed:8432706, ECO:0000269|PubMed:9501185}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
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| nucleotide Binding |
|
| Features |
Chain (1); Frameshift (1); Mutagenesis (21); Region (2); Site (1) |
| Keywords |
Cell cycle;Cell division;DNA damage;Reference proteome;SOS response;Septation |
| Interact With |
P0A6H5 |
| Induction |
INDUCTION: By DNA damage, as part of the SOS response, repressed by LexA (PubMed:3297925). Induced 8-fold by hydroxyurea (at protein level) (PubMed:20005847). {ECO:0000269|PubMed:20005847, ECO:0000269|PubMed:3297925}. |
| Subcellular Location |
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| Modified Residue |
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| Post Translational Modification |
PTM: Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired. {ECO:0000269|PubMed:10788793, ECO:0000269|PubMed:11513747, ECO:0000269|PubMed:6300834, ECO:0000269|PubMed:9180687}. |
| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10209756;
12670962;
19395483;
21803990;
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| Motif |
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| Gene Encoded By |
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| Mass |
18,801 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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