| IED ID | IndEnz0002009138 |
| Enzyme Type ID | protease009138 |
| Protein Name |
Serpin B5 Maspin Peptidase inhibitor 5 PI-5 |
| Gene Name | Serpinb5 Pi5 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MDALRLANSAFAVELFKQLCEKEPAGNILFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFKPITSDVNKLSSFYSLKLIKRLYIDKSLNLSTEFISSTKRPYANELETVDFKDKLEETKGQINSSIKELTDGHFEDILPENSISDQTKILVVNAAYFVGKWMKKFPESETKECPFRINKTDTKPVQMMNLEATFCLGNIDDINCKIIELPFQNKHLSMLIVLPKDVEDESTGLEKIEKQLNPETLLQWTNPSTMANAKVKLSLPKFKVEKMIDPKASLESLGLKSLFNESTSDFSGMSETKGVSVSNVIHRVCLEITEDGGDSIEVPGSRILQHKDEFKADHPFLFIVRHNKTRNIVFLGKFSSP |
| Enzyme Length | 375 |
| Uniprot Accession Number | P70564 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (5); Site (1) |
| Keywords | Glycoprotein;Reference proteome;Secreted |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17563239; 17950367; 21069375; 32746986; 34059749; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,063 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |