| IED ID | IndEnz0002009163 |
| Enzyme Type ID | protease009163 |
| Protein Name |
Inactive rhomboid protein 2 iRhom2 Rhomboid family member 2 |
| Gene Name | rhbdf2 |
| Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Silurana Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Enzyme Sequence | MASLKKNGSSSRLQDRKPPNLSITIPPVEGERDPKLMQPLTKPVFQKSVSLQEPRGHVAEGGTADVRPGFKRQTSLSQSIKRGTAQWFGVSNDWEGKRQQWQRKSLHHCSLRYGKLKPQYQRDIELPSQETPSFQATESPATHRLPKIVDPLARGRPFRHPDEVDRPRTPHVGLPPQTPGMLSLASFTSVRSGYSRFPRRKRESVAHMSFRAAAALIKGRPILDTPHSRKAGQKRSFIYPSFMDEDTVDAAETLDSSFFSKVDMHDETFSMPDDVFDSPPMSASYFRAPLPIPELMPGAAIEAAKEPVKSVQVYTPDHRRGKRIASQVKHFAFDRKKRLYGLGVVGSWLNRTYRRSISSTVQSQLEHFNSHRPYFAYWITFVHILITILAIATYGIAPIGFAQHTTSELVLRNKGVYESVKYIQQENFWIGPSSIALIHLGAKFSPCIRYDEQIKNLIEKQHGLERESGCCIQNDKSGCVQTHRKDCSETLATFIKWPEHDAPVLDEVTGMKRTSGAVCHQDPRTCEEPASIQPHVWADDITKWPICTYQAMNNHTGIRHMDCEIKGRPCCIGTKGSCEITTREYCTFMHGYFHEEATLCSQVHCLDEVCGLLPFLNPEYPDQFYRLWLSLFLHAGVIHCCVSVVFQMTVLRDLEKLAGWLRISIIYILSGITGNLASALFLPYRAEVGPAGSQFGLLACLFVELFQSWQILAKPWKAFLKLLGIVLFLFLFGLLPWIDNIAHIFGFLSGLLLSFSFLPYITFGTADKFRKRAMIIISLLVFVGLFASLVIWLYVYPINWAWIEYLTCLPFTNKFCEKYDIDQVLH |
| Enzyme Length | 826 |
| Uniprot Accession Number | A0JPA1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (2); Region (3); Topological domain (8); Transmembrane (7) |
| Keywords | Cell membrane;Endoplasmic reticulum;Growth factor binding;Membrane;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q80WQ6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80WQ6}. Cell membrane {ECO:0000250|UniProtKB:Q6PJF5}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 93,843 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |