| IED ID | IndEnz0002009200 |
| Enzyme Type ID | protease009200 |
| Protein Name |
Transferrin-binding protein B TbpB Transferrin-binding protein 2 TBP-2 |
| Gene Name | tbpB tbp2 NMA2025 |
| Organism | Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Neisseria Neisseria meningitidis Neisseria meningitidis serogroup A Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) |
| Enzyme Sequence | MNNPLVNQAAMVLPVFLLSACLGGGGSFDLDSVDTEAPRPAPKYQDVSSEKPQAQKDQGGYGFAMRLKRRNWYRQANPKEDEIKLSENDWEQTDNGDIKNPSKQKNIINALTGNNGGASLQDSSQENQGISKVTGHHNFQYVWSGFFYKQIGSTFERKDSSITAARSGPDGYIFYKGKDPSRKLPVSGEVMYKGTWDFLTDVKTSQKFTDLGNTSTRPGDRYSAFSGELDYIVNKDSDKKDEHVGWGLTTEITVDFEKKTLSGKLIKNNRVNNDNDKHTTQYYSLDATLRGNRFSGKAEATDKPKNDGETKEHPFVSDSSSLSGGFFGPKGEELGFRFLSDDQKVAVVGSAKTQDKPRNGAVASGGAGAAASNGAAGTSSENSKLTTVLDAVELTLNDKKIKNLDNFSNAAQLVVDGIMIPLLPEASESGKNQANQGTNGGTAFTRKFNHTPKSDEKDTQAGTAENGNPAASNTAGDANGKTKTYEVEVCCSNLNYLKYGMLTRKNSKSAMQAGESSSQADAKTEQVGQSMFLQGERTDEKEIPNDQNVVYRGSWYGHIANGTSWSGNASDKEGGNRADFTVNFGTKKINGTLTADNRQAATFTIVGDIEGNGFSGTAKTADSGFDLDQSNNTRTPKAYITNAKVQGGFYGPKAEELGGWFAYSDDKQTKNATDASGNGNSASSATVVFGAKRQKPVQ |
| Enzyme Length | 698 |
| Uniprot Accession Number | O68937 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Neisseria acquires iron by extracting it from serum transferrin (TF) in its human host. Acts as a TF receptor and is required for TF utilization. Involved in the initial capture of TF. Helps select only those TF molecules that can be used as an iron source and concentrates them on the cell surface, maintaining the iron-loaded status of the TF C-terminal lobe until its delivery to TbpA. {ECO:0000250|UniProtKB:Q09057}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (5); Lipidation (2); Region (6); Signal peptide (1) |
| Keywords | Cell outer membrane;Lipoprotein;Membrane;Palmitate;Receptor;Signal;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell surface {ECO:0000250|UniProtKB:Q06988}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 75,176 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |