| IED ID | IndEnz0002009204 |
| Enzyme Type ID | protease009204 |
| Protein Name |
Snake venom metalloproteinase BleucMP SVMP EC 3.4.24.- Fragment |
| Gene Name | |
| Organism | Bothrops leucurus (Whitetail lancehead) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops leucurus (Whitetail lancehead) |
| Enzyme Sequence | TLTSFGEWR |
| Enzyme Length | 9 |
| Uniprot Accession Number | P0DJJ6 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by EDTA and 1,10-phenanthroline. Not inhibited by beta-mercaptoethanol, benzamidine and aprotinin. {ECO:0000269|PubMed:21130897}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Snake venom zinc metalloprotease that has fibrino(geno)lytic activities. Hydrolyzes the alpha-chain (FGA) and more slowly the beta-chain of fibrinogen (FGB), without affecting the gamma-chain. Preferentially hydrolyzes the beta-chain (FGB) of fibrin. In vivo, shows a low edema-inducing effect. This action may be attributed to degradation of proteins in the cell membrane and consequent release of inflammatory mediators and leukocyte infiltrate. {ECO:0000269|PubMed:21130897}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Non-terminal residue (2) |
| Keywords | Direct protein sequencing;Disulfide bond;Fibrinogenolytic toxin;Fibrinolytic toxin;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Toxin;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Contains 7 disulfide bonds. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 1,096 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |