| IED ID | IndEnz0002009217 |
| Enzyme Type ID | protease009217 |
| Protein Name |
Mitochondrial-processing peptidase subunit alpha Alpha-MPP Inactive zinc metalloprotease alpha Matrix processing peptidase MPP Mitochondrial assembly protein 2 Mitochondrial import function protein 2 |
| Gene Name | MAS2 MIF2 YHR024C |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MLRNGVQRLYSNIARTDNFKLSSLANGLKVATSNTPGHFSALGLYIDAGSRFEGRNLKGCTHILDRLAFKSTEHVEGRAMAETLELLGGNYQCTSSRENLMYQASVFNQDVGKMLQLMSETVRFPKITEQELQEQKLSAEYEIDEVWMKPELVLPELLHTAAYSGETLGSPLICPRELIPSISKYYLLDYRNKFYTPENTVAAFVGVPHEKALELTEKYLGDWQSTHPPITKKVAQYTGGESCIPPAPVFGNLPELFHIQIGFEGLPIDHPDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTHVLNQYYFVENCVAFNHSYSDSGIFGISLSCIPQAAPQAVEVIAQQMYNTFANKDLRLTEDEVSRAKNQLKSSLLMNLESKLVELEDMGRQVLMHGRKIPVNEMISKIEDLKPDDISRVAEMIFTGNVNNAGNGKGRATVVMQGDRGSFGDVENVLKAYGLGNSSSSKNDSPKKKGWF |
| Enzyme Length | 482 |
| Uniprot Accession Number | P11914 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. {ECO:0000269|PubMed:9299349}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (14); Chain (1); Helix (22); Sequence conflict (1); Transit peptide (1); Turn (6) |
| Keywords | 3D-structure;Direct protein sequencing;Mitochondrion;Reference proteome;Transit peptide |
| Interact With | P10507 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:2007593}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 1HR6; 1HR7; 1HR8; 1HR9; |
| Mapped Pubmed ID | 10449402; 10496979; 10545606; 11368022; 11805826; 11805837; 12191769; 12791261; 1447206; 15458388; 16429126; 16554755; 17263664; 17445721; 19536198; 19930686; 20053354; 20124346; 22172993; 2229072; 22663076; 24058582; 25079602; 25435547; 26446170; 2905264; 6235522; 7586024; 9737975; 9829989; |
| Motif | |
| Gene Encoded By | |
| Mass | 53,338 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.64; |