| IED ID | IndEnz0002009225 |
| Enzyme Type ID | protease009225 |
| Protein Name |
Ubiquitin thioesterase OTU1 EC 3.4.19.12 |
| Gene Name | yod1 DDB_G0271346 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MSLISIRIRSKTGVENIKLESQLKLKELQNIIEEKTKISTDTQKILYGFPPKALDLSNQDAVISGFLANGDTITIENVSSISSNPGVDSVTNDKVTSSTNSFDRNIKSQPFISQEEEEDGGYATRRVTDDDNSCLFSAVAYVLEDKNRLKGYSLRALIAQNVKSDPFEYNEAVLGKSNEGYCNWIQNPKNWGGAIELSILSNHYKVEIAAFDISTQLMYCYGEDRKYTERVYLIYDGIHYDALSICLTKNGPEDFDITRFSVDDKDSLAKMKVLIEKEFKAGKFTDTAKFSLICLNCNKTLKGEKEAAIHASTTGHGNFTEYKKR |
| Enzyme Length | 325 |
| Uniprot Accession Number | Q55BI3 |
| Absorption | |
| Active Site | ACT_SITE 131; /evidence=ECO:0000250|UniProtKB:Q96FW1; ACT_SITE 134; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:Q5VVQ6; ACT_SITE 239; /evidence=ECO:0000250|UniProtKB:Q5VVQ6; ACT_SITE 316; /evidence=ECO:0000250|UniProtKB:Q96FW1 |
| Activity Regulation | |
| Binding Site | BINDING 238; /note=Substrate; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q5VVQ6 |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q5VVQ6}; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. {ECO:0000250|UniProtKB:Q5VVQ6}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (4); Binding site (1); Chain (1); Domain (1); Region (5); Zinc finger (1) |
| Keywords | Cytoplasm;Hydrolase;Metal-binding;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway;Zinc;Zinc-finger |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5VVQ6}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17659086; |
| Motif | |
| Gene Encoded By | |
| Mass | 36,456 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |