| IED ID | IndEnz0002009244 |
| Enzyme Type ID | protease009244 |
| Protein Name |
Deubiquitinase OTUD6B EC 3.4.19.12 |
| Gene Name | OTUD6B RCJMB04_24h18 |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MEGSEDEEAEAGGPLQQLVKRQRREKRELQAKIQGMKNAVPKNDKKRRKQLAEEVAKLEAELEQKHKEELKQLKEAMPEQNKIDSIADGVANFELEGREQQIQHPRISKAQKRREKKAALEKEREERIAEAEIENLTGARHLESQKLASLLAARHLEIKQIPSDGHCMYRAIEDQLKDHHNSWTVATLRNQTAKYIHSHFDDFLPFLTNPNTGDMYSKEEFEKYCDDIANTAAWGGQLELRALSHILQTPIEVVQMDSPSIIVGEEYSGKPIILVYMRHAYGLGEHYNSVKLLTDATTENGS |
| Enzyme Length | 302 |
| Uniprot Accession Number | Q5ZIP6 |
| Absorption | |
| Active Site | ACT_SITE 164; /evidence=ECO:0000250; ACT_SITE 167; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:Q8N6M0; ACT_SITE 286; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q8N6M0}; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes. {ECO:0000250|UniProtKB:Q8N6M0}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Domain (1); Region (5) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 34,542 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |