| IED ID | IndEnz0002009245 |
| Enzyme Type ID | protease009245 |
| Protein Name |
Deubiquitinase OTUD6B EC 3.4.19.12 |
| Gene Name | otud6b zgc:56305 |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MEEVETAEEQLAKQHRKEKKDLQAKIQSMKNAVPKNDKKRRKQLTEDIAKLEAELSQKHENELKLQNTSSVEEVSDALDSMSVANHEEQSDPSKQSRTSKAQKRRDKKAALEKEREMRIAEAEVENLSGSRHQEGLKLREKLVERHLQIKEISSDGHCMYRAVEHQLTERGLALGLKELRDQTAQYMRSHADDFMPFLTNPNTGDMYTAEEFEKYCSDVADTAAWGGQLELKALSQVLQLPIEVIQADSPCITIGEEYDKPKITLIYMRHAYGLGEHYNSVEPLKDLANEEEG |
| Enzyme Length | 293 |
| Uniprot Accession Number | Q7ZV00 |
| Absorption | |
| Active Site | ACT_SITE 155; /evidence=ECO:0000250; ACT_SITE 158; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:Q8N6M0; ACT_SITE 277; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q8N6M0}; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes. {ECO:0000250|UniProtKB:Q8N6M0}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (3); Domain (1); Region (5) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 33,507 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |