| IED ID | IndEnz0002009262 |
| Enzyme Type ID | protease009262 |
| Protein Name |
Ubiquitin thioesterase otubain-like EC 3.4.19.12 Deubiquitinating enzyme otubain-like Ubiquitin-specific-processing protease otubain-like |
| Gene Name | otub-1 CBG11576 |
| Organism | Caenorhabditis briggsae |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis briggsae |
| Enzyme Sequence | MVNDTSENQPTTAGIVTTTEDELILQDQQMKRIEDEQKASPLVGEKMPCATLVSLYDQETAPAFFEKANELAKVYSHIRFIRGDGNCFIRAIQVGLVEILLNDKERLVKFIASCKEWTERLVKLGFPDWTCTDFCEFFIEFIEKVRDGIHQKEDVFRIFNDDNTANYLLMFFRLITSGYLKEHAAEYEPFLDEGMSLAQYCETEIEAMWKESDHLGIIALVRALNIRIRIEYMDRNAAPNGGTHHNLPDGHDNATFTPDITLLYRPGHYDLIYKAPAETSKPALPPVA |
| Enzyme Length | 288 |
| Uniprot Accession Number | A8XDJ2 |
| Absorption | |
| Active Site | ACT_SITE 84; /evidence=ECO:0000250|UniProtKB:Q96FW1; ACT_SITE 87; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:Q96DC9; ACT_SITE 244; /evidence=ECO:0000250|UniProtKB:Q96FW1; ACT_SITE 268; /evidence=ECO:0000250|UniProtKB:Q96FW1 |
| Activity Regulation | |
| Binding Site | BINDING 175; /note=Substrate; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q5VVQ6 |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q96DC9}; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (4); Binding site (1); Chain (1); Domain (1) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 32,949 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |