| IED ID | IndEnz0002009273 |
| Enzyme Type ID | protease009273 |
| Protein Name |
Pregnancy-associated glycoprotein 1 PAG 1 EC 3.4.23.- Pregnancy-specific protein B PSP-B |
| Gene Name | |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MKWLVLLGLVAFSECIVKIPLRRLKTMRNVVSGKNMLNNFLKEHAYSLSQISFRGSNLTTHPLRNIKDLVYMGNITIGTPPQEFQVVFDTASSDLWVPSDFCTSPACSTHVRFRHLQSSTFRLTNKTFRITYGSGRMKGVVVHDTVRIGNLVSTDQPFGLSIEEYGFEGRIYDGVLGLNYPNISFSGAIPIFDKLKNQRAISEPVFAFYLSKDEREGSVVMFGGVDHRYYEGELNWVPLIQAGDWSVHMDRISIERKIIACSDGCKALVDTGTSDIVGPRRLVNNIHRLIGAIPRGSEHYVPCSEVNTLPSIVFTINGINYPVPGRAYILKDDRGRCYTTFQENRVSSSTETWYLGDVFLRLYFSVFDRGNDRIGLARAV |
| Enzyme Length | 380 |
| Uniprot Accession Number | Q29432 |
| Absorption | |
| Active Site | ACT_SITE 89; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 270; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Appears to be proteolytically inactive. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (3); Domain (1); Glycosylation (4); Propeptide (1); Sequence conflict (3); Signal peptide (1) |
| Keywords | Aspartyl protease;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | PTM: N-Glycosylated; the glycans terminate in either N-acetyl-galactosamine (GalNAc) or N-acetyllactosamine (PubMed:17071780, PubMed:15822115). Terminal GalNAc on Asn-linked glycans is greatly reduced prior to parturition while lactosamine-type N-glycans remain unaltered (PubMed:17071780). {ECO:0000269|PubMed:15822115, ECO:0000269|PubMed:17071780}. |
| Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,847 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |