| IED ID | IndEnz0002009292 |
| Enzyme Type ID | protease009292 |
| Protein Name |
Ovalbumin Allergen Gal d II Egg albumin Plakalbumin allergen Gal d 2 |
| Gene Name | SERPINB14 |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MGSIGAASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPGFGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFKGLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSMLVLLPDEVSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITDVFSSSANLSGISSAESLKISQAVHAAHAEINEAGREVVGSAEAGVDAASVSEEFRADHPFLFCIKHIATNAVLFFGRCVSP |
| Enzyme Length | 386 |
| Uniprot Accession Number | P01012 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Non-inhibitory serpin. Storage protein of egg white. {ECO:0000269|PubMed:3732511, ECO:0000269|PubMed:6749856}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (17); Chain (1); Disulfide bond (1); Glycosylation (1); Helix (14); Initiator methionine (1); Metal binding (1); Modified residue (3); Mutagenesis (3); Natural variant (2); Sequence conflict (3); Signal peptide (1); Site (2); Turn (9) |
| Keywords | 3D-structure;Acetylation;Allergen;Calcium;Direct protein sequencing;Disulfide bond;Glycoprotein;Metal-binding;Phosphoprotein;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: Down-regulated by dietary stress. Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens. {ECO:0000269|PubMed:25436390}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6749856}. |
| Modified Residue | MOD_RES 2; /note="N-acetylglycine"; /evidence="ECO:0000269|PubMed:272676, ECO:0000269|PubMed:751625"; MOD_RES 69; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:6783411"; MOD_RES 345; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:6783411" |
| Post Translational Modification | PTM: Undergoes proteolytic cleavage first at the canonical P1-P1' site, and then at the P8-P7 site by subtilisin. {ECO:0000269|PubMed:11779232, ECO:0000269|PubMed:11931671}. |
| Signal Peptide | SIGNAL 22..48; /note=Not cleaved |
| Structure 3D | X-ray crystallography (12) |
| Cross Reference PDB | 1JTI; 1OVA; 1P1Z; 1P4L; 1UHG; 1VAC; 3C8K; 3CVH; 3P9L; 3P9M; 3PAB; 4HKJ; |
| Mapped Pubmed ID | 12840013; 14595439; 18426793; 18703505; 22039305; 23209377; 26312056; 7708669; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,881 |
| Kinetics | |
| Metal Binding | METAL 192; /note=Calcium |
| Rhea ID | |
| Cross Reference Brenda |