| IED ID | IndEnz0002009363 |
| Enzyme Type ID | protease009363 |
| Protein Name |
Inactive rhomboid protein 2 iRhom2 Rhomboid family member 2 Rhomboid veinlet-like protein 6 Rhomboid-related protein |
| Gene Name | Rhbdf2 Irhom2 Rhbdl6 Rhor |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MASADKNGSNLPSVSGSRLQSRKPPNLSITIPPPESQAPGEQDSMLPERRKNPAYLKSVSLQEPRGRWQEGAEKRPGFRRQASLSQSIRKSTAQWFGVSGDWEGKRQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPKIVDPLARGRAFRHPDEVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLPRRKRISVAHMSFQAAAALLKGRSVLDATGQRCRHVKRSFAYPSFLEEDAVDGADTFDSSFFSKEEMSSMPDDVFESPPLSASYFRGVPHSASPVSPDGVHIPLKEYSGGRALGPGTQRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHIIITLLVICTYGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQIEQLVRRERDIERTSGCCVQNDRSGCIQTLKKDCSETLATFVKWQNDTGPSDKSDLSQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAQSNHTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMHGYFHEDATLCSQVHCLDKVCGLLPFLNPEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPWIDNIAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVLWLYIYPINWPWIEYLTCFPFTSRFCEKYELDQVLH |
| Enzyme Length | 827 |
| Uniprot Accession Number | Q80WQ6 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:21439629}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Modified residue (6); Region (1); Sequence conflict (1); Topological domain (8); Transmembrane (7) |
| Keywords | Endoplasmic reticulum;Membrane;Phosphoprotein;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | Q9Z0F8; P78536 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21439629}; Multi-pass membrane protein {ECO:0000269|PubMed:21439629}. |
| Modified Residue | MOD_RES 60; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319"; MOD_RES 83; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319"; MOD_RES 87; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319"; MOD_RES 293; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"; MOD_RES 295; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"; MOD_RES 298; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079" |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12466851; 12573256; 12904583; 14610273; 15102471; 16615898; 17967808; 18799693; 21494248; 21677750; 22246777; 22246778; 22550345; 23348744; 23801765; 23969955; 24825892; 25395669; 25546423; 25918388; 27393687; 27428826; 27601030; 27626380; 28033581; 28104813; 28128203; 28268192; 28432785; 28655741; 28965953; 29045841; 29116018; 29155878; 29369823; 29415889; 29491382; 29523849; 29776906; 29897333; 30097271; 30165303; 30694569; 31153974; 31586441; 31662486; 31918923; 32060096; 32094386; 32103528; 32135161; 32180551; 32592194; 32646486; 33227998; 33429334; 33950315; 33957124; |
| Motif | |
| Gene Encoded By | |
| Mass | 93,434 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |