Detail Information for IndEnz0002009375
IED ID IndEnz0002009375
Enzyme Type ID protease009375
Protein Name Signal peptidase complex catalytic subunit SEC11
EC 3.4.21.89
Signal peptidase I
Gene Name SEC11 SCHCODRAFT_56459
Organism Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetidae Agaricales Schizophyllaceae Schizophyllum Schizophyllum commune (Split gill fungus) Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
Enzyme Sequence MFSEELKAFRRLGIRHLLLQALNFASVIASGLMMWKGLGVITNTESPIVVVLSGSMEPAFYRGDLLFLTNPSGVRFHTGDITVYKVPNGDIPIVHRVLETHEIAPNATFVPHKYNRAYTPEDQLLLTKGDNNPIDDTGLYTQGMDWLERKHIVGKVRGFVPYVGYATIAMNDFPQLKYGLLGILGLMALIQRE
Enzyme Length 193
Uniprot Accession Number D8Q7Q5
Absorption
Active Site ACT_SITE 55; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P15367; ACT_SITE 95; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P15367; ACT_SITE 136; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P15367
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; EC=3.4.21.89; Evidence={ECO:0000250|UniProtKB:P15367};
DNA Binding
EC Number 3.4.21.89
Enzyme Function FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity). {ECO:0000250|UniProtKB:P15367, ECO:0000250|UniProtKB:P67812}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Glycosylation (1); Region (1); Topological domain (2); Transmembrane (1)
Keywords Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P15367}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P15367}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 21,588
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda