Detail Information for IndEnz0002009377
IED ID IndEnz0002009377
Enzyme Type ID protease009377
Protein Name Signal peptidase complex catalytic subunit SEC11A
EC 3.4.21.89
Endopeptidase SP18
Microsomal signal peptidase 18 kDa subunit
SPase 18 kDa subunit
SEC11 homolog A
SEC11-like protein 1
SPC18
Gene Name SEC11A SEC11L1
Organism Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Ponginae Pongo Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Enzyme Sequence MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITGSESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKQNGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFKYAVLFLLGLFVLVHRE
Enzyme Length 179
Uniprot Accession Number Q5R9C7
Absorption
Active Site ACT_SITE 56; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P67812; ACT_SITE 96; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P67812; ACT_SITE 122; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P67812
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; EC=3.4.21.89; Evidence={ECO:0000250|UniProtKB:P67812};
DNA Binding
EC Number 3.4.21.89
Enzyme Function FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids. {ECO:0000250|UniProtKB:P67812}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Region (1); Topological domain (2); Transmembrane (1)
Keywords Endoplasmic reticulum;Hydrolase;Membrane;Protease;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P67811}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P67811}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 20,625
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda