| IED ID | IndEnz0002009386 |
| Enzyme Type ID | protease009386 |
| Protein Name |
Serine protease inhibitor 42Dd Serpin 42Dd |
| Gene Name | Spn42Dd Spn1 CG9456 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MYYLCIFLWVTSVACQTSKEIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSEDKEAVAARYGALLNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAERINQWVLDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPVQMMAQMGTFRANYFRDLDAQVIELPYLNSNLSMTIFLPREVEGLSALEEKIVGFARPLVAKEVYLKLPKFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQVSHKAFLEVNEEGAEAAGATSVAVTNRAGFSTFLMADHPFAFVIRDANTIYFQGRVVSP |
| Enzyme Length | 372 |
| Uniprot Accession Number | Q7YTY6 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. {ECO:0000269|PubMed:21576362}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (2); Sequence conflict (1); Signal peptide (1) |
| Keywords | Glycoprotein;Immunity;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | INDUCTION: Up-regulated by the Gram-positive bacterium M.luteus, the fungus B.bassiana and the yeast C.albicans. {ECO:0000269|PubMed:21576362}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12601174; 14605208; 14667416; 15056610; 15864439; 15979870; 18666829; 19171888; 19343724; 19849829; 20220848; 20371351; 20813047; 21074052; 21480662; 21683256; 21900267; 21940639; 22368770; 22952997; 23071443; 23109270; 23550122; 23632253; 23840627; 24349561; 25096240; 26173873; 27172210; 31722958; 31794428; 32656090; 33377870; |
| Motif | |
| Gene Encoded By | |
| Mass | 41,179 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |