| IED ID | IndEnz0002009465 |
| Enzyme Type ID | protease009465 |
| Protein Name |
26S proteasome non-ATPase regulatory subunit 14 EC 3.4.19.- 26S proteasome regulatory subunit RPN11 Sks1 multidrug resistance protein homolog |
| Gene Name | psmD14 sks1 DDB_G0272566 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MNRSLMSLLGREGLGEKITDATPLPDTAETIHISSLALLKMLQHARAGVPLEVMGLMLGELIDEYTIRVIDVFAMPQSGTSVSVEAIDPVFQTKMLDMLKQTGRDEIVIGWYHSHPGFGCWLSSVDVNTQQSFEQLQSRAVAVVVDPLQSVRGKVVIDAFRTIKTSPTAEPRQITSNLGHLQDPSIQALIHGLNRNYYSIAINYRKNELEQKMLLNLHKKKWTEGLIVDKFDTHEQSNEKQINNLLELTKQYQKSIQDEDKIEPEKKEVSAVGKLDPKRHLISDVHTLMANNVVRVLTVMLDTVTF |
| Enzyme Length | 306 |
| Uniprot Accession Number | Q86IJ1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.19.- |
| Enzyme Function | FUNCTION: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Metal binding (3); Motif (1); Sequence conflict (1) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Protease;Proteasome;Reference proteome;Ubl conjugation pathway;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 19482547; 22120990; |
| Motif | MOTIF 113..126; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By | |
| Mass | 34,451 |
| Kinetics | |
| Metal Binding | METAL 113; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 115; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 126; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Rhea ID | |
| Cross Reference Brenda |