| IED ID |
IndEnz0002009472 |
| Enzyme Type ID |
protease009472 |
| Protein Name |
26S proteasome regulatory subunit RPN10
|
| Gene Name |
RPN10 MCB1 SUN1 YHR200W |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Saccharomycotina (true yeasts)
Saccharomycetes
Saccharomycetales
Saccharomycetaceae
Saccharomyces
Saccharomyces cerevisiae (Baker's yeast)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
|
| Enzyme Sequence |
MVLEATVLVIDNSEYSRNGDFPRTRFEAQIDSVEFIFQAKRNSNPENTVGLISGAGANPRVLSTFTAEFGKILAGLHDTQIEGKLHMATALQIAQLTLKHRQNKVQHQRIVAFVCSPISDSRDELIRLAKTLKKNNVAVDIINFGEIEQNTELLDEFIAAVNNPQEETSHLLTVTPGPRLLYENIASSPIILEEGSSGMGAFGGSGGDSDANGTFMDFGVDPSMDPELAMALRLSMEEEQQRQERLRQQQQQQDQPEQSEQPEQHQDK |
| Enzyme Length |
268 |
| Uniprot Accession Number |
P38886 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Multiubiquitin binding protein. {ECO:0000269|PubMed:8887631}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (10); Chain (1); Domain (2); Helix (7); Initiator methionine (1); Region (1) |
| Keywords |
3D-structure;Direct protein sequencing;Proteasome;Reference proteome;Ubl conjugation |
| Interact With |
P48510; P38764; P33297 |
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
PTM: Ubiquitinated, leading to its degradation (PubMed:17190603). Ubiquitination is promoted by HUL5 (PubMed:17190603). {ECO:0000269|PubMed:17190603}. |
| Signal Peptide |
|
| Structure 3D |
Electron microscopy (23); X-ray crystallography (1) |
| Cross Reference PDB |
3JCO;
3JCP;
4CR2;
4CR3;
4CR4;
5A5B;
5LN1;
5MPB;
5MPC;
5MPD;
5MPE;
5WVI;
5WVK;
6FVT;
6FVU;
6FVV;
6FVW;
6FVX;
6FVY;
6J2C;
6J2N;
6J2Q;
6J2X;
6J30;
|
| Mapped Pubmed ID |
10363642;
10471701;
10508607;
10559920;
10664589;
10688918;
10873636;
11283351;
11742986;
11805826;
11805837;
11830665;
12051757;
12052895;
12235853;
12589471;
12853471;
12860974;
14644450;
14759368;
15117949;
15168522;
15242647;
15258615;
15380085;
15544949;
15571806;
15572408;
15601860;
15610744;
15652483;
15699485;
15826667;
15837425;
15905137;
15907469;
16056265;
16207362;
16284124;
16429126;
16541108;
16554755;
16922378;
17010312;
17082762;
17107617;
17499717;
17644757;
17916559;
17945519;
17978571;
18054791;
18497817;
18725537;
18757749;
18995839;
19153599;
19387488;
19446322;
19446323;
19536198;
19587678;
20059542;
20064467;
20074027;
20204449;
20430475;
20542005;
20603003;
20800707;
20941496;
21095592;
21139140;
21179020;
21288874;
21427232;
21454622;
21543789;
21627799;
21685082;
22081111;
22086954;
22140548;
22215586;
22350874;
22350895;
22356687;
22434192;
22949210;
23105008;
23217712;
23545414;
23672618;
23770819;
24037519;
24201294;
24429290;
24598877;
24681338;
24706844;
24997605;
25311859;
25333764;
25631053;
26130806;
26205498;
26262643;
26450923;
26670610;
26929360;
27092291;
27099939;
27677933;
27693354;
27698474;
28069708;
28106073;
28115689;
30067984;
30792173;
8125911;
8882582;
9228276;
9442033;
9512348;
9584156;
9697412;
9741626;
9790993;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
29,747 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|