| IED ID | IndEnz0002009489 |
| Enzyme Type ID | protease009489 |
| Protein Name |
Kunitz-type protease inhibitor 2 Hepatocyte growth factor activator inhibitor type 2 HAI-2 |
| Gene Name | Spint2 Hai2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MAQLCELRRGRALLALVASLLLSGAQVASRELDVHESCGVSKVVGKCRASIPRWWYNITDGSCQPFVYGGCEGNGNNYQSKEECLDKCAGVTENTTDDMARNRNGADSSVLSVPRKQSAEDLSAEIFNYEEYCVPKAVTGPCRAAFPRWYYDTEKNSCISFIYGGCRGNKNSYLSQEACMQHCSGKQMHPFLTPGLKAVILVGLFLMVLILLLGTSMVCLIRVVRRKQERALRTVWSTADDKEQLVKNTCVL |
| Enzyme Length | 252 |
| Uniprot Accession Number | Q9WU03 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibitor of HGF activator. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Chain (1); Disulfide bond (6); Domain (2); Glycosylation (2); Signal peptide (1); Site (2); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Disulfide bond;Glycoprotein;Membrane;Protease inhibitor;Reference proteome;Repeat;Serine protease inhibitor;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10725249; 11217851; 11406276; 11431694; 11798188; 12466851; 12520002; 12604353; 12904583; 14610273; 15339983; 17452023; 18554416; 18713750; 18799693; 18973680; 19334288; 19592578; 20152175; 21267068; 21677750; 21898507; 22952456; 24952961; 24962579; 27385010; 29617460; 30623107; 31628112; 34003106; |
| Motif | |
| Gene Encoded By | |
| Mass | 27,914 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |