| IED ID | IndEnz0002009573 |
| Enzyme Type ID | protease009573 |
| Protein Name |
STAM-binding protein-like EC 3.4.19.- |
| Gene Name | stambp |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MPEHSDASLPPEERIRALVLKGTSVEVNDDIPPKRYYRSGVELIRMANVYSGEGSIENAFILYNKYITLFIEKLPKHRDYKTANVPEKKETLKKLKEIAFPKAEELKKELHKRYKKEYEEYSEKQRKEEEERARRLALQQQLDAEKQRVALLKQQQEQQEQVQAFEEMMRRKELEAERLRILHQFSKDEPEAEPLGSPLIPGMNEPPVTPLLPSYGTVQPHPPAVDRSLKPSSYGSNSSGVTSDGLRHVKIPRDVCCKFLQLSENNTQRGVETCGILCGKLLQNEFTVTHVIVPKQSGGPDYCNTESEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLTDYGMKEIGECRQKGFHPHCKEPPLFSAGGHVSVTEQDVTMMDLR |
| Enzyme Length | 416 |
| Uniprot Accession Number | Q63ZM7 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.19.- |
| Enzyme Function | FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Domain (1); Metal binding (7); Motif (1); Region (1); Site (1) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Protease;Ubl conjugation pathway;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 327..340; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By | |
| Mass | 47,595 |
| Kinetics | |
| Metal Binding | METAL 327; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 329; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 340; /note=Zinc 1; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 342; /note=Zinc 2; /evidence=ECO:0000250; METAL 382; /note=Zinc 2; /evidence=ECO:0000250; METAL 388; /note=Zinc 2; /evidence=ECO:0000250; METAL 390; /note=Zinc 2; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |