| IED ID | IndEnz0002009577 |
| Enzyme Type ID | protease009577 |
| Protein Name |
Trypsin-1 EC 3.4.21.4 Trypsin I |
| Gene Name | |
| Organism | Gadus morhua (Atlantic cod) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Euteleosteomorpha Neoteleostei Eurypterygia Ctenosquamata Acanthomorphata Paracanthopterygii Zeiogadaria Gadariae Gadiformes (cods and others) Gadoidei Gadidae (cods) Gadus Gadus morhua (Atlantic cod) |
| Enzyme Sequence | MKSLIFVLLLGAVFAEEDKIVGGYECTKHSQAHQVSLNSGYHFCGGSLVSKDWVVSAAHCYKSVLRVRLGEHHIRVNEGTEQYISSSSVIRHPNYSSYNINNDIMLIKLTKPATLNQYVHAVALPTECAADATMCTVSGWGNTMSSVADGDKLQCLSLPILSHADCANSYPGMITQSMFCAGYLEGGKDSCQGDSGGPVVCNGVLQGVVSWGYGCAERDHPGVYAKVCVLSGWVRDTMANY |
| Enzyme Length | 241 |
| Uniprot Accession Number | P16049 |
| Absorption | |
| Active Site | ACT_SITE 59; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 103; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 195; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; |
| DNA Binding | |
| EC Number | 3.4.21.4 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (14); Chain (1); Disulfide bond (6); Domain (1); Helix (3); Propeptide (1); Sequence conflict (4); Signal peptide (1); Site (1); Turn (3) |
| Keywords | 3D-structure;Digestion;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..13; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 2EEK; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 25,941 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |