| IED ID | IndEnz0002009590 |
| Enzyme Type ID | protease009590 |
| Protein Name |
Tolloid-like protein 1 EC 3.4.24.- Chicken tolloid-like protein 1 Metalloprotease colloid |
| Gene Name | TLL1 |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MKMLCWRLALWLAAWAVCGKPSFCSALDYDYTYDFTEEDKAEAIDYKDPCKAAVFWGDIALDDEDLKIFQIDRTIDLTQHSNERLGHNTGGFGEHGMSKKRGALYQLIERIRRFGSGFEQNNTSKGRTTVKFSGKNEKNRFPRAATSRTERIWPGGVIPYVIGGNFTGTQRAMFKQAMRHWEKYTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKMEPGEVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESTGNFSSPGFPNGYPSYTHCIWRISVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLASSDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIHKNEGQIQSPNYPDDYRPMKECVWKITVSENYNVGLTFQAFEIERHDNCAYDYLEIRDGMNENSPLIGHFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEMMCQPDNGGCEQRCVNTLGSYQCACDPGYELGPDKKSCEAACGGLLTKLNGTIPTPGWPKEYPPNKNCVWQVVAPTQYRISMKFEFFELEGNEVCKYDYVEIRSGLSSDSKLHGKFCGTEVPEVITSQYNNMRIEFRSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECINTVGSYVCQCRNGFVLHENKHDCKEAECEQKIHSPNGIIMSPNWPDKYPSRKECTWEISATPGQRVKLTFNEFEIEQHQECAYDHLEVFDGESEKSPILGRLCGSKIPEPLIATGNKMFLRFISDASVQRKGFQATHSTECGGRLKAETKPKDLYSHAQFGDNNYPVQADCDWLLVAERGYRVELMFQTFEVEEEADCGYDYVELFDGHDKTAMRLGRFCGSGPPEEIYSAGETLLLHFHTDDTINKKGFHIRYRSIKYPDSVHTKK |
| Enzyme Length | 1008 |
| Uniprot Accession Number | Q9DER7 |
| Absorption | |
| Active Site | ACT_SITE 237; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Protease which processes procollagen C-propeptides, such as chordin, probiglycan and prolysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (19); Domain (8); Glycosylation (5); Metal binding (3); Propeptide (1); Signal peptide (1) |
| Keywords | Calcium;Developmental protein;Differentiation;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10940628}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..26; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 114,891 |
| Kinetics | |
| Metal Binding | METAL 236; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 240; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 246; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda |