| IED ID | IndEnz0002009595 |
| Enzyme Type ID | protease009595 |
| Protein Name |
Probable threonine protease PRSS50 EC 3.4.25.- Cancer/testis antigen 20 Serine protease 50 Testis-specific protease-like protein 50 |
| Gene Name | PRSS50 CT20 TSP50 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGRWCQTVARGQRPRTSAPSRAGALLLLLLLLRSAGCWGAGEAPGALSTADPADQSVQCVPKATCPSSRPRLLWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRANGTHICAGTIIASQWVLTVAHCLIWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDTHREKFCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSRTLLLALPLPLSLLAAL |
| Enzyme Length | 385 |
| Uniprot Accession Number | Q9UI38 |
| Absorption | |
| Active Site | ACT_SITE 153; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 206; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 310; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.25.- |
| Enzyme Function | FUNCTION: May be involved in proteolysis through its threonine endopeptidase activity. {ECO:0000269|PubMed:17283160}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (4); Domain (1); Glycosylation (2); Mutagenesis (1); Natural variant (2); Signal peptide (1) |
| Keywords | Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Protease;Reference proteome;Signal;Threonine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305|PubMed:17283160}. Note=May also localize to cytoplasmic membranes. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..39; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11782390; 15491742; 18462069; 18662669; 20506264; 21765952; 22574111; 25049081; 25077921; 25312478; 25399078; 25640309; 25811800; 27039397; 27109614; 28631709; 28650473; 29361914; 33630390; 33956530; 34016961; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,088 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |