| IED ID | IndEnz0002009611 |
| Enzyme Type ID | protease009611 |
| Protein Name |
Ninjurin-A dNINJ-A Cleaved into: Secreted ninjurin-A |
| Gene Name | NijA ninA CG6449 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MSNLEHITLEMDKVPLGDNKTLVRNTENISKHSYGGAIDGRTRNTLRVPRAVPETDDDDNDDRPFVKDGNDNPGVDDGLFSTVGGNGGNGGNVNVNVPNGGRRPSFSFPGYNGPGFVTINGVETPIPDVNAYQHKKTLAQGMMDLALLSANANQLRYVLETSSQHPYFYPSLLFISLSIIFQIAVGVGLILNGQYNIKNGHDICRANRINNYTVSGIFIVTVVNVLISAFTVDRDTVPALPANTT |
| Enzyme Length | 245 |
| Uniprot Accession Number | Q8MPP0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: [Ninjurin-A]: Homophilic transmembrane adhesion molecule involved in non-apoptotic necrotic cell death (PubMed:23028562). Promotes cell adhesion by mediating homophilic interactions via its extracellular region (By similarity). Probably involved in non-apoptotic necrotic cell death by mediating plasma membrane rupture (cytolysis), leading to release intracellular molecules that propagate the inflammatory response (PubMed:33472215). {ECO:0000250|UniProtKB:O70131, ECO:0000269|PubMed:23028562, ECO:0000269|PubMed:33472215}.; FUNCTION: [Secreted ninjurin-A]: Secreted form generated by cleavage, which acts as a negative regulator of cell adhesion (PubMed:16815999). Promotes the loss of cell adhesion in a cell non-autonomous manner (PubMed:16815999). {ECO:0000269|PubMed:16815999}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Chain (2); Compositional bias (2); Glycosylation (2); Region (1); Topological domain (3); Transmembrane (2) |
| Keywords | Alternative splicing;Cell adhesion;Cell membrane;Cytolysis;Glycoprotein;Membrane;Reference proteome;Secreted;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | INDUCTION: Up-regulated upon injury. {ECO:0000269|PubMed:16815999}. |
| Subcellular Location | SUBCELLULAR LOCATION: [Ninjurin-A]: Cell membrane {ECO:0000269|PubMed:23028562, ECO:0000305|PubMed:16815999}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secreted ninjurin-A]: Secreted {ECO:0000269|PubMed:16815999}. |
| Modified Residue | |
| Post Translational Modification | PTM: [Ninjurin-A]: Cleaved by Mmp1 protease to generate the Secreted ninjurin-A form. {ECO:0000269|PubMed:16815999}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12431377; 12466201; 14602076; 17705839; 19218090; 20220848; 20371351; 21074052; 21963537; 22496733; 22496853; 22817988; 22851689; 23071443; 23637905; 23792147; 23922788; 23944235; 25217625; 25312911; 26173873; 26979755; 29670218; 29750417; 30543770; 31722958; 32598400; |
| Motif | |
| Gene Encoded By | |
| Mass | 26,491 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |