| IED ID | IndEnz0002009614 |
| Enzyme Type ID | protease009614 |
| Protein Name |
NLR family CARD domain-containing protein 4 Ice protease-activating factor Ipaf |
| Gene Name | nlrc4 ipaf TGas028l14.1 |
| Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Silurana Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Enzyme Sequence | MDLIRKNYAELVQRMGRTIAVQITNDLFTRNILSMGEMEEILSCKVAQDLTRELLNVILKKGTESCTRLLQSLENQDPFFYEDLIGQRVQSGVTEEDLENLADHLKRLYQYPFFKKFNPLGEDTDIDIIFDLDRTFTDPLLWRKGTLNRREKQLTLSEMLEQLESPCVIEGEAGKGKTTILKRIAMLWASEKCRALADFKLVFFVTLRGASEGLYETLSDQLFPITYSWNKKEFLNKIWHLGRKVLFLLDGYDEFQSESCTEIEELIKNNPKFNSTVIVSTRTETIGKLRRCGALIAETSDFSLDNAKQLIANVLEEDEANGLLFQLEESSFMQNLMKTPLFVVIACALRMGESDFQMNTQTTLFSTLYDLMVEKKKYKIRHLSANILAANIRKFGDLALDGLFEQRFDFNEKHLSKIKEEVLLNIGLLNKYTAQRRKAVYRYFHTTFQEYIAGRRLSQLLSSEDNSDVTKGEDFLNKIVSVFDITTKYKNLLLYTCGSSKVATQKVVKHVAEVHKHDKNNYSTELVEFGLNLFFESSTKKELSQDFETLFSEKCLYINSHNISSHHIEFFLYLPNCLSALQLIKLDLSGTFATVPSESTMDRDSKSAQSSVCDNYIPEKAVKLFFDWNQSIQTLEVTLRDFHQLNKKDIKYLGKICCSADSLRLNIKRSSGITGSLVGVLESCKNIQDLNVDSTKLSIEDERRIVQMTEMKTLSILNLHSEHLQGGLLEGLCNLVGLEKLVFHNIKIDKNDAKTLAEGILSLKKLKRLSISHISNIGDGMESIAESISLCCHELKELKLIDCCLSAKALRSLGQSLYSLSHIEILDLSGNYLLEEGKESVEELAANLTHLDAIRTLMLPGGTDVKFCLEAVLPTLRRIPTLSELAFKRWNLTNDDLMTLASYINSGFENLSFLDLSDNCAQSAGWLSLTAILQYLPNLTYVNFSTEDLFTPDPDLVRKLVRAISALPLLHTMELNNWQLDDFDLAQIKKAKNMIHR |
| Enzyme Length | 997 |
| Uniprot Accession Number | F6R2G2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 171..178; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00136 |
| Features | Chain (1); Domain (2); Nucleotide binding (1); Region (2); Repeat (12); Sequence conflict (1) |
| Keywords | ATP-binding;Apoptosis;Cytoplasm;Immunity;Inflammatory response;Innate immunity;Leucine-rich repeat;Nucleotide-binding;Reference proteome;Repeat |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 113,626 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |