| IED ID | IndEnz0002009618 |
| Enzyme Type ID | protease009618 |
| Protein Name |
Proteinase-activated receptor 1 PAR-1 Coagulation factor II receptor Thrombin receptor |
| Gene Name | F2R CF2R PAR1 TR |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT |
| Enzyme Length | 425 |
| Uniprot Accession Number | P25116 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269|PubMed:10079109}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (3); Chain (1); Disulfide bond (1); Glycosylation (5); Helix (13); Modified residue (1); Mutagenesis (1); Natural variant (6); Propeptide (1); Sequence conflict (2); Signal peptide (1); Site (2); Topological domain (8); Transmembrane (7); Turn (2) |
| Keywords | 3D-structure;Blood coagulation;Cell membrane;Disulfide bond;G-protein coupled receptor;Glycoprotein;Hemostasis;Membrane;Phosphoprotein;Receptor;Reference proteome;Signal;Transducer;Transmembrane;Transmembrane helix |
| Interact With | Q03135; Q9UNN8 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. |
| Modified Residue | MOD_RES 418; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163 |
| Post Translational Modification | PTM: Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand (PubMed:1672265, PubMed:7744748). Also proteolytically cleaved by cathepsin CTSG (PubMed:7744748). Cleavage at 41-Arg-|-Ser-42 by CTSG results in receptor activation while cleavage at 55-Phe-|-Trp-56 results in inhibition of receptor activation (PubMed:7744748). {ECO:0000269|PubMed:1672265, ECO:0000269|PubMed:7744748}.; PTM: Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor. {ECO:0000269|PubMed:8955127}. |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000269|PubMed:22659187 |
| Structure 3D | X-ray crystallography (10) |
| Cross Reference PDB | 1NRN; 1NRO; 1NRP; 1NRQ; 1NRR; 3BEF; 3HKI; 3HKJ; 3LU9; 3VW7; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 47,441 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |