| IED ID |
IndEnz0002009709 |
| Enzyme Type ID |
protease009709 |
| Protein Name |
Inactive serine protease scarface
|
| Gene Name |
scaf scarf CG11066 |
| Organism |
Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Diptera
Brachycera
Muscomorpha
Eremoneura
Cyclorrhapha
Schizophora
Acalyptratae
Ephydroidea
Drosophilidae (pomace flies)
Drosophilinae
Drosophilini
Drosophila (fruit flies)
Sophophora
melanogaster group
melanogaster subgroup
Drosophila melanogaster (Fruit fly)
|
| Enzyme Sequence |
MSASHFREQLALCITLAVLAAASGDYRANMFLNGQYQNGIKDQKENNLLVNPSTNVFLNHAIISRQASPFQGPTYLPPKEFLKCAPGQQCVRSGQCLNGYFAQQLPKIQNCDPETTVCCTYRPPPTTTTTTTTSVPVANCAYDSDCVTPDNCRNGEISAINYVKKQGPNRCPAPNICCRIPSTTLTEDGYIFNLPEKTFPLPTKPAVLAMPSTQAPFRPQPTTAVPASRPTIEYLPPSTTQHPSYEKVQTSRRPVYLPPSPATESASSLIPKIRPRPEPRPQPTRRPTNEYLPPAAANEIPRFEPDRAPQPSNQKPIYRGEDQLSPQIFPTPQPANVPKHFAKCASALVCTSENFCNAIGVLSETPVELSPMEAAFRVPLTDCLQTENGSPGKCCRDPNYVDPWPVNLAGVCATRNKRTKPTGVKDLDANFAEIPWQAMILRESSKTLICGGAIIGDQFVLSSASCVNGLPVTDIRVKAGEWELGSTNEPLPFQLTGVKTVDVHPDYDPSTNSHDLAIIRLERRLEFASHIQPICISDEDPKDSEQCFTSGWGKQALSIHEEGALMHVTDTLPQARSECSADSSSVCSATKFDSCQFDVGSALACGSGSSVRLKGIFAGENSCGEGQTVRFAKPDIKWINTAFAENNKPLLLKRF |
| Enzyme Length |
655 |
| Uniprot Accession Number |
Q7K5M0 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Inactive serine protease that plays a role in germ-band retraction and dorsal closure morphogenesis in embryogenesis; contributes to amnioserosa attachment and epithelial apico-basal polarity by regulating the localization of laminin LanA on the apical side of the amnioserosa epithelium (PubMed:28628612, PubMed:20379222). Contributes to epithelial morphogenesis probably by regulating the bsk/JNK pathway, as part of a negative-feedback loop, and by modulating the cross-talk between the Egfr, bsk/JNK and dpp signal transduction pathways (PubMed:28628612, PubMed:20379222). In larval development, antagonizes the morphogenetic movements controlled by the bsk/JNK signaling including male genitalia formation and thorax development (PubMed:20379222, PubMed:20530545, PubMed:25737837). {ECO:0000269|PubMed:20379222, ECO:0000269|PubMed:20530545, ECO:0000269|PubMed:25737837, ECO:0000269|PubMed:28628612}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (1); Disulfide bond (7); Domain (1); Region (2); Signal peptide (1) |
| Keywords |
Developmental protein;Disulfide bond;Reference proteome;Secreted;Serine protease homolog;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15342518, ECO:0000269|PubMed:20379222, ECO:0000269|PubMed:20530545}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
12431377;
12568721;
12827380;
15020470;
15640802;
16369566;
17996400;
18628398;
19000837;
20220848;
21074052;
21205821;
21278706;
22904080;
23071443;
23109363;
24585718;
24956222;
25242144;
25312911;
25426014;
25647511;
26207831;
26453810;
26526100;
26998322;
27513559;
28231245;
28634244;
29776969;
30232002;
30367934;
32681087;
33322177;
34120097;
34210781;
34216545;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
71,417 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|