| IED ID | IndEnz0002009800 |
| Enzyme Type ID | protease009800 |
| Protein Name |
Serpin H1 47 kDa heat shock protein Collagen-binding protein Colligin Serine protease inhibitor J6 |
| Gene Name | Serpinh1 Cbp1 Hsp47 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MRSLLLGTLCLLAVALAAEVKKPLEAAAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWASQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQMVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKAWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPKGDKMRDEL |
| Enzyme Length | 417 |
| Uniprot Accession Number | P19324 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (3); Modified residue (5); Motif (1); Sequence conflict (7); Signal peptide (1); Site (1) |
| Keywords | Acetylation;Chaperone;Direct protein sequencing;Endoplasmic reticulum;Glycoprotein;Phosphoprotein;Reference proteome;Signal;Stress response |
| Interact With | |
| Induction | INDUCTION: By heat shock and retinoic acid. |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. |
| Modified Residue | MOD_RES 93; /note=N6-succinyllysine; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 140; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P50454; MOD_RES 206; /note=N6-acetyllysine; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 295; /note=N6-succinyllysine; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 318; /note=N6-acetyllysine; /evidence=ECO:0007744|PubMed:23806337 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000269|PubMed:1317794 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10862616; 10995453; 12466851; 12748967; 12842808; 1309665; 14610273; 15121863; 15282337; 15522896; 15582152; 16326708; 16484215; 16525016; 16602821; 18093850; 18799693; 19411759; 19521500; 20094730; 21144841; 21335239; 21606205; 21862448; 22159717; 22295344; 22492985; 22925884; 23212911; 23269685; 23587755; 23624931; 24292013; 24295791; 24454956; 24586547; 24650661; 25525267; 26091621; 26196532; 26921296; 27076780; 27477081; 28071719; 28802097; 29351844; 29363541; 29512284; 30786278; 31393098; 32562852; 32714072; 32716577; 34244516; 7656593; 7905876; 8018053; 8187816; 8269704; 8299716; 8848834; 8944545; 9294190; 9853961; 9880236; 9880238; |
| Motif | MOTIF 414..417; /note=Prevents secretion from ER; /evidence=ECO:0000305 |
| Gene Encoded By | |
| Mass | 46,534 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |