| IED ID | IndEnz0002009844 |
| Enzyme Type ID | protease009844 |
| Protein Name |
Ufm1-specific protease 2 UfSP2 EC 3.4.22.- |
| Gene Name | Ufsp2 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLNDLTTKLSSDALVFRICNSSVYLWPNSDANTGELTDSSACKSVVDLIQFDQEEDTKRKFMKKKDKKLTDMQQIVNIDLMLEISTPLGAVTPIIERENEEHHYINMSLPIDAVVSVAPEETWGKVRKLLVDAILNQLVDVEKCILRYMKGTSIVVPEPLHFLLPGGKNLVTVLYPSGIPDDQLQAYRKELHDLFKLPHDRPYLKRINAYHFPDELYKDGYIRNPHAYLSPPNIEGSMICMVQGTYAYHHYMQNRVDDNGWGCAYRSLQTVCSWFRHQGYTERAIPTHREIQQALVDAGDKPATFVGSRQWIGSIEVQLVLNQLIGVTSKILFVNQGSEMASQGRELANHFQNVGTPVMIGGGVLAHTILGVAWNETTGQIKFLILDPHYTGAEDLQVILEKGWCGWKGPDFWNKDAYYNLCLPQRPNAL |
| Enzyme Length | 461 |
| Uniprot Accession Number | Q5XIB4 |
| Absorption | |
| Active Site | ACT_SITE 294; /evidence=ECO:0000250|UniProtKB:Q99K23; ACT_SITE 418; /evidence=ECO:0000250|UniProtKB:Q99K23; ACT_SITE 420; /evidence=ECO:0000250|UniProtKB:Q99K23 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation. {ECO:0000250|UniProtKB:Q99K23, ECO:0000250|UniProtKB:Q9NUQ7}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1) |
| Keywords | Cytoplasm;Endoplasmic reticulum;Hydrolase;Nucleus;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99K23}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99K23}. Nucleus {ECO:0000250|UniProtKB:Q99K23}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 52,307 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |