| IED ID | IndEnz0002009890 |
| Enzyme Type ID | protease009890 |
| Protein Name |
Inactive rhomboid protein 1 iRhom1 Epidermal growth factor receptor-related protein Rhomboid 5 homolog 1 Rhomboid family member 1 p100hRho |
| Gene Name | RHBDF1 C16orf8 DIST1 IRHOM1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH |
| Enzyme Length | 855 |
| Uniprot Accession Number | Q96CC6 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Erroneous gene model prediction (3); Erroneous initiation (1); Glycosylation (1); Modified residue (5); Mutagenesis (3); Natural variant (1); Sequence conflict (4); Topological domain (8); Transmembrane (7) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Growth factor binding;Membrane;Phosphoprotein;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | Q9UBR4-2 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18832597}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane (PubMed:15965977). {ECO:0000269|PubMed:15965977}. |
| Modified Residue | MOD_RES 76; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 176; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 180; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 183; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q6PIX5; MOD_RES 390; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163 |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000269|PubMed:15965977}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20379614; 20970119; 24648344; 26109405; 26535007; 29654741; 29727209; 30279141; 31661139; |
| Motif | |
| Gene Encoded By | |
| Mass | 97,401 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |