| IED ID | IndEnz0002009892 |
| Enzyme Type ID | protease009892 |
| Protein Name |
Protein Rex Rev homolog Rex-2 |
| Gene Name | |
| Organism | Human T-cell leukemia virus 2 (HTLV-2) |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Deltaretrovirus Primate T-lymphotropic virus 2 Human T-cell leukemia virus 2 (HTLV-2) |
| Enzyme Sequence | MPKTRRQRTRRARRNRPPTPWPISQDLDRASYMDTPSTCLAIVYRPIGVPSQVVYVPPAYIDMPSWPPVQSTNSPGTPSMDALSALLSNTLSLASPPSPPREPQGPSRSLPLPPLLSPPRFHLPSFNQCESTPPTEMDAWNQPSGISSPPSPSPNLASVPKTSTPPGEKP |
| Enzyme Length | 170 |
| Uniprot Accession Number | Q85601 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Rex escorts unspliced gag-pro-pol and singly spliced env mRNAs out of the nucleus of infected cells. These mRNAs carry a recognition sequence called Rex responsive element (RxRE or XRE) located at the 3' region of the long terminal repeat (LTR). This function is essential since most HTLV proteins are translated from unspliced or partially spliced pre-mRNAs that cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:10482560}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (4); Modified residue (2); Motif (2); Mutagenesis (34); Region (4) |
| Keywords | Host cytoplasm;Host nucleus;Phosphoprotein;RNA-binding;Reference proteome;Transport;mRNA transport |
| Interact With | Q96FJ2; Q8N448; Q9GZT8 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Host nucleus, host nucleolus {ECO:0000250}. Host cytoplasm {ECO:0000250}. Note=The presence of both nuclear import (NLS) and nuclear export (NES) signals leads to continuous shuttling between the nucleus and cytoplasm. {ECO:0000250}. |
| Modified Residue | MOD_RES 151; /note=Phosphoserine; by host; /evidence=ECO:0000269|PubMed:11507189; MOD_RES 153; /note=Phosphoserine; by host; /evidence=ECO:0000269|PubMed:11507189 |
| Post Translational Modification | PTM: Phosphorylation is essential for RNA-binding and function. {ECO:0000269|PubMed:11507189}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 22458338; |
| Motif | MOTIF 2..19; /note="Nuclear localization signal, and RNA-binding (RxRE)"; /evidence="ECO:0000250"; MOTIF 83..94; /note="Nuclear export signal"; /evidence="ECO:0000250" |
| Gene Encoded By | |
| Mass | 18,463 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |