| IED ID | IndEnz0002009922 |
| Enzyme Type ID | protease009922 |
| Protein Name |
Serpin B4 Leupin Peptidase inhibitor 11 PI-11 Squamous cell carcinoma antigen 2 SCCA-2 |
| Gene Name | SERPINB4 PI11 SCCA2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSHGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFSSP |
| Enzyme Length | 390 |
| Uniprot Accession Number | P48594 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May act as a protease inhibitor to modulate the host immune response against tumor cells. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Modified residue (1); Sequence conflict (1); Site (1) |
| Keywords | Acetylation;Cytoplasm;Direct protein sequencing;Protease inhibitor;Reference proteome;Serine protease inhibitor |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10956412}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level. |
| Modified Residue | MOD_RES 1; /note=N-acetylmethionine; /evidence=ECO:0000269|Ref.6 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12437110; 12702576; 14630915; 14970861; 15677460; 16211231; 16549498; 16820864; 17016656; 17353931; 18097581; 19070595; 19339807; 19596235; 19615732; 19956912; 19959474; 20428762; 20562859; 21182205; 21338226; 21576355; 21857942; 22406480; 22451727; 22576068; 22808225; 22937809; 23168150; 24189400; 24366813; 24560885; 24635038; 24898082; 25111616; 25213322; 26963506; 26993499; 27668655; 28734739; 28766361; 29106998; 29112685; 29122495; 29421276; 29491058; 29712495; 30078551; 30825353; 30905447; 31091854; 31815365; 33839977; 34878006; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,854 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |