| IED ID | IndEnz0002009966 |
| Enzyme Type ID | protease009966 |
| Protein Name |
Metacaspase-1 EC 3.4.22.- |
| Gene Name | MCA1 CNBJ2750 |
| Organism | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Tremellales (jelly fungi) Cryptococcaceae Cryptococcus Cryptococcus neoformans species complex Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus neoformans var. neoformans Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Enzyme Sequence | MSWNQYPGGGHHQQGGYGYRPPPPQWAQQGPPPPPNMGYRPPPPPQAYYNNPPPPQQYQRPAPQQNGYQQGGYQQQQQSQGNYRTSNGGYVPPTGAPVEASYHHTGAGYTPPSGTPQRTSAPYGAGAPIRPPSQAQHYGPQLQGQGGQSAQPYFQYSQCTGKKKALCIGINYVGSSSALAGCINDAHNVQKFLIERYGYKSEDIVMLTDDARNPRQIPTRANILAAMHWLVQGAQPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPLDFKTAGHIVDDDITDCKGRHNIMVRPLPAGCRLTAIYDSCHSGTALDLPYIYSTEGVIKEPNLLAEAGQGLLSAGMSYLRGDTGGMLQGIMGIGKKVMNQNSGAMEKARQTKTSPADVISWSGCKDSQTSADTQEAGRATGAMSYAFIAALTKYPQQSYVQLLNTIRDELKGKYDQKPQLSASHPMDTNILFIC |
| Enzyme Length | 463 |
| Uniprot Accession Number | P0CM59 |
| Absorption | |
| Active Site | ACT_SITE 247; /evidence=ECO:0000250; ACT_SITE 309; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (2); Erroneous gene model prediction (1); Propeptide (1); Region (1) |
| Keywords | Apoptosis;Hydrolase;Protease;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 50,236 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |