| IED ID | IndEnz0002009967 |
| Enzyme Type ID | protease009967 |
| Protein Name |
Dynamin-like GTPase MGM1, mitochondrial Mitochondrial division and morphology protein 17 Mitochondrial genome maintenance protein 1 Cleaved into: Dynamin-like GTPase MGM1 large isoform l-MGM1 ; Dynamin-like GTPase MGM1 small isoform s-MGM1 |
| Gene Name | MGM1 MDM17 YOR211C YOR50-1 |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MNASPVRLLILRRQLATHPAILYSSPYIKSPLVHLHSRMSNVHRSAHANALSFVITRRSISHFPKIISKIIRLPIYVGGGMAAAGSYIAYKMEEASSFTKDKLDRIKDLGESMKEKFNKMFSGDKSQDGGHGNDGTVPTATLIAATSLDDDESKRQGDPKDDDDEDDDDEDDENDSVDTTQDEMLNLTKQMIEIRTILNKVDSSSAHLTLPSIVVIGSQSSGKSSVLESIVGREFLPKGSNMVTRRPIELTLVNTPNSNNVTADFPSMRLYNIKDFKEVKRMLMELNMAVPTSEAVSEEPIQLTIKSSRVPDLSLVDLPGYIQVEAADQPIELKTKIRDLCEKYLTAPNIILAISAADVDLANSSALKASKAADPKGLRTIGVITKLDLVDPEKARSILNNKKYPLSMGYVGVITKTPSSINRKHLGLFGEAPSSSLSGIFSKGQHGQSSGEENTNGLKQIVSHQFEKAYFKENKKYFTNCQVSTKKLREKLIKILEISMSNALEPTSTLIQQELDDTSYLFKVEFNDRHLTPKSYLLNNIDVLKLGIKEFQEKFHRNELKSILRAELDQKVLDVLATRYWKDDNLQDLSSSKLESDTDMLYWHKKLELASSGLTKMGIGRLSTMLTTNAILKELDNILESTQLKNHELIKDLVSNTAINVLNSKYYSTADQVENCIKPFKYEIDLEERDWSLARQHSINLIKEELRQCNSRYQAIKNAVGSKKLANVMGYLENESNLQKETLGMSKLLLERGSEAIFLDKRCKVLSFRLKMLKNKCHSTIEKDRCPEVFLSAVSDKLTSTAVLFLNVELLSDFFYNFPIELDRRLTLLGDEQVEMFAKEDPKISRHIELQKRKELLELALEKIDSILVFKKSYKGVSKNL |
| Enzyme Length | 881 |
| Uniprot Accession Number | P32266 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane. {ECO:0000269|PubMed:10037792, ECO:0000269|PubMed:12566426, ECO:0000269|PubMed:12707284, ECO:0000269|PubMed:15087460}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 217..224; /note=GTP; /evidence=ECO:0000255; NP_BIND 317..321; /note=GTP; /evidence=ECO:0000255; NP_BIND 385..388; /note=GTP; /evidence=ECO:0000255 |
| Features | Beta strand (15); Chain (2); Compositional bias (1); Domain (2); Erroneous initiation (3); Frameshift (1); Helix (29); Mutagenesis (12); Nucleotide binding (3); Region (6); Sequence conflict (3); Topological domain (2); Transit peptide (1); Transmembrane (1); Turn (3) |
| Keywords | 3D-structure;Direct protein sequencing;GTP-binding;Hydrolase;Membrane;Mitochondrion;Mitochondrion inner membrane;Nucleotide-binding;Reference proteome;Signal-anchor;Transit peptide;Transmembrane;Transmembrane helix |
| Interact With | P38297; Q03327 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Dynamin-like GTPase MGM1 large isoform]: Mitochondrion inner membrane {ECO:0000269|PubMed:15096522}; Single-pass type II membrane protein {ECO:0000255}; Intermembrane side {ECO:0000305|PubMed:15096522}. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.; SUBCELLULAR LOCATION: [Dynamin-like GTPase MGM1 small isoform]: Mitochondrion inner membrane {ECO:0000269|PubMed:15096522}; Peripheral membrane protein {ECO:0000269|PubMed:15096522}; Intermembrane side. |
| Modified Residue | |
| Post Translational Modification | PTM: Cleavage of the transit peptide by mitochondrial processing protease (MPP) produces a long integral membrane form of MGM1 (l-MGM1). Further processing by the rhomboid protease PCP1 produces a short peripheral membrane form of MGM1 (s-MGM1). Both isoforms are required for full activity. {ECO:0000269|PubMed:15096522}. |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 6JSJ; |
| Mapped Pubmed ID | 10066164; 10873824; 11038180; 11038181; 11038192; 11731314; 12052774; 12123827; 12774122; 12776123; 12791261; 12901865; 15040446; 15125685; 15689974; 16093310; 16218949; 16285870; 16429126; 16571363; 16725216; 16737747; 16754953; 16778770; 17043137; 17055438; 17263664; 17331506; 17362197; 17445721; 17506702; 17696775; 17959383; 18372247; 18454199; 18605900; 18691613; 18951795; 19236101; 19240798; 19453275; 19505460; 19536198; 19575675; 19638617; 19703904; 19751518; 19752025; 19825355; 19841731; 20006727; 20025987; 20225023; 20558178; 20835916; 20929674; 20946356; 20950655; 21326212; 21457713; 21471218; 21846491; 21912203; 21936844; 22480867; 22541440; 22550491; 22663076; 22748693; 22808334; 22977249; 23045528; 23124206; 23166736; 23184936; 23837470; 23932848; 23956814; 23994494; 24007978; 24099009; 24205865; 24240771; 2453298; 24771456; 24866973; 24884775; 24954468; 25435547; 25454944; 25601284; 25753536; 25784211; 26035862; 26455272; 26552703; 26764088; 27061938; 27068958; 27145142; 27502471; 27502688; 27693354; 27804052; 27849155; 32041880; 9891785; |
| Motif | |
| Gene Encoded By | |
| Mass | 99,178 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |