| IED ID | IndEnz0002009986 |
| Enzyme Type ID | protease009986 |
| Protein Name |
Vacuolar membrane protease EC 3.4.-.- FXNA-related family protease 1 |
| Gene Name | CAWG_04918 |
| Organism | Candida albicans (strain WO-1) (Yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Candida/Lodderomyces clade Candida Candida albicans (Yeast) Candida albicans (strain WO-1) (Yeast) |
| Enzyme Sequence | MSEEEVHDTSSEASEVFTNQPNAFVRGVRSIFGYRKTSLTLFVILTIVVTAGLSFYDNSLELTIELPTSQLEKEILESSWLDLQNIARYPHTYGSRANDQVHDYLEEIIQDMEYDNDGEKIMFESGKGVVSYYESNNLLVRVNGSDGTLPALLLSAHYDSVPSSFGVTDDGMGVASLLGVLRFVAHNQPRRTIIFNFNNNEEFGLFGAHAFVKHPWFKQVGYFLNLEGTGAGGKAVLFRGTDYGIVKNFGGVRYPYATSIFQQGFNNHVIHSETDYKVYKEAGLRGLDLAFYKPRDKYHTGEDNIRNVSPKSLWHMMSNAIDFVQMGVVDDSEEPAVYTTFLGYFFATPISALARVNLVLLVLFPVVSTPLLFVIVKYKKWKLRVTNFLGVPLAMGLAVAVGQVGNPMLVSSHPMMVVATTTSIVVLVYYVVLNGVDWVNTSSDQKLVTMIEVSFVYWVVLVYVTWSGGDHTGEFGVTVLFFVQASTSLLGLIGWTFTRVRGGDEPLLSGEEERYGTEDERDTEKPLVEHNYDWSLQYLLIVPVSSLVVYNSGWLVLEGVNKTVQESLASEHLIYWIVVVFSQFLVLPVVPFITKFNRYIVLGLSVVAVVGVLMSMAVHPFNQGSPMKLRFIERVGQNDMVEVYGRQGFVEDVLSDLPSVKQTQAKLECEALPDGLEVCKYKSGLTPGNLTVEVTTEPRAESYGLISGAITIAAPENRMCTVHFPPDRVKAVVVGKFGNNFKAIPDGFSREKGNYIYKDRNGISQLELYKLDWNKDYHVGFEWLPDIDDEGGMRVEVECFWGDMVPAYQEVVHYSPNWVTWANKERGLVGVVKHVDV |
| Enzyme Length | 837 |
| Uniprot Accession Number | C4YS59 |
| Absorption | |
| Active Site | ACT_SITE 201; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (3); Metal binding (6); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Transmembrane;Transmembrane helix;Vacuole;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 93,732 |
| Kinetics | |
| Metal Binding | METAL 157; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 169; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 169; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 202; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 227; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 299; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |