| IED ID | IndEnz0002010010 |
| Enzyme Type ID | protease010010 |
| Protein Name |
Retinol-binding protein 3 Interphotoreceptor retinoid-binding protein IRBP Interstitial retinol-binding protein |
| Gene Name | Rbp3 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MMREWVLVLSTLLWVPAGPTHLFQPSLVLDMAKILLDNYCFPENLMGMQAAIEQAMKSHEILGISDPQTLAQVLTAGVQSSLSDPRLFISYEPSTLEAPQQAPVLTNLTREELLAQIQRNIRHEVLEGNVGYLRVDDLPGQEVLSELGEFLVSHVWRQLMGTSSLVLDLRHCSGGHFSGIPYVISYLHPGNTVMHVDTVYDRPSNTTTEIWTLPEVLGERYSADKDVVVLTSGHTGGVAEDIAYILKQMRRAIVVGERTEGGALDLQKLRIGQSNFFLTVPVSRSLGPLGGGGQTWEGSGVLPCVGTPAEQALEKALAILTLRRALPGVVLRLQEALQDYYTLVDRVPGLLHHLASMDYSAVVSEEDLVTKLNAGLQAVSEDPRLLVRATGPRDSSSRPETGPNESPAATPEVPTEEDARRALVDSVFQVSVLPGNVGYLRFDRFADAAVLETLGPYVLKQVWEPLQDTEHLIMDLRHNPGGPSSAMPLVLSYFQGPEAGPVRLFTTYDRRTNITQEHFSHRELLGQRYGNQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGSLLHTCTVPLLDSPQGGLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALERAQEVLDFHRSLGALVEGTGRLLEAHYARPEIAQRARALLQSKLAQGAYRTAVDLESLASQLTADLQEVSEDHRLLVFHSPGELVAEEVPLPPPAVPSPEELSYLIEALFKTDVLPGQLGYLRFDAMAELETVKAIGPQLVQLVWQRLVDTAALIVDLRYNPGSYSSAVPLLCSYFFEAEPRQHLYSVFDRATSRVTEIWTLPLVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGNSPLYASMPTQMALSASTGEAWDLAGVEPDITVPMSEALSTAQDIVVLRAKVPTVLQTAGKLVADNYASPELGAKMAAKLSGLQSRYARVTSEGALAEMLGADLQILSGDPHLKTAHIPEDAKDRIPGIVPMQIPSPEVFEDLIKFSFHTNVLEDNIGYLRFDMFGDCELLTQVSELLVEHIWKKIVHTDALIIDMRFNLGGPTSSISALCSYFFDEAPPILLDKIYNRPNDSVSELWTHTQLTGERYGSKKSVAILTSGVTAGAAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTHLYITIPTARSVGAEDGSSWEGVGVTPNVVVSSELALTRAKEILQQALRG |
| Enzyme Length | 1234 |
| Uniprot Accession Number | P49194 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (3); Region (2); Repeat (4); Sequence conflict (4); Signal peptide (1) |
| Keywords | Extracellular matrix;Glycoprotein;Reference proteome;Repeat;Secreted;Signal;Transport;Vitamin A |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10508404; 10602050; 10750831; 11278819; 11468275; 11821982; 12096340; 14599843; 14657219; 14744875; 15226823; 15635294; 16110338; 1655359; 16585264; 17116738; 17270348; 18436827; 19193895; 19357286; 19542467; 19844803; 20238012; 20463215; 21430170; 21613504; 21642628; 21779340; 22238462; 22552229; 2276745; 23486466; 24174679; 25593512; 25692504; 26152845; 26287682; 27046120; 28972139; 29109151; 30636608; 32290105; 33755662; 7818535; 7822029; 8157102; 8313988; 8679252; 8812413; 8833241; 9434938; 9441761; 9479006; 9614228; 9843205; |
| Motif | |
| Gene Encoded By | |
| Mass | 134,451 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |