| IED ID | IndEnz0002010023 |
| Enzyme Type ID | protease010023 |
| Protein Name |
Protein Tax-2 Trans-activating transcriptional regulatory protein of HTLV-2 |
| Gene Name | tax |
| Organism | Human T-cell leukemia virus 2 (HTLV-2) |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Ortervirales Retroviridae Orthoretrovirinae Deltaretrovirus Primate T-lymphotropic virus 2 Human T-cell leukemia virus 2 (HTLV-2) |
| Enzyme Sequence | MAHFPGFGQSLLYGYPVYVFGDCVQADWCPVSGGLCSTRLHRHALLATCPEHQLTWDPIDGRVVSSPLQYLIPRLPSFPTQRTSRTLKVLTPPTTPVSPKVPPAFFQSMRKHTPYRNGCLEPTLGDQLPSLAFPEPGLRPQNIYTTWGKTVVCLYLYQLSPPMTWPLIPHVIFCHPRQLGAFLTKVPLKRLEELLYKMFLHTGTVIVLPEDDLPTTMFQPVRAPCIQTAWCTGLLPYHSILTTPGLIWTFNDGSPMISGPYPKAGQPSLVVQSSLLIFEKFETKAFHPSYLLSHQLIQYSSFHNLHLLFDEYTNIPVSILFNKEEADDNGD |
| Enzyme Length | 331 |
| Uniprot Accession Number | P03410 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Induces T-cell transformation, although much less efficiently than HTLV-1. Required for viral replication (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Modified residue (5); Motif (2); Region (7); Sequence conflict (5); Zinc finger (1) |
| Keywords | Activator;DNA-binding;G0/G1 host cell cycle checkpoint dysregulation by virus;Host cytoplasm;Host nucleus;Host-virus interaction;Metal-binding;Modulation of host cell cycle by virus;Oncogene;Phosphoprotein;Reference proteome;SH3-binding;Transcription;Transcription regulation;Zinc;Zinc-finger |
| Interact With | Q96MT8; O43186; O14964; Q6PEX3; Q8N448; Q9BRK4; P82932; Q6ZVK8; P35711; Q9NZD8; Q9Y2D8 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:15269214}. Host nucleus {ECO:0000269|PubMed:15269214}. Note=Tax-2 is mainly found in the cytoplasm. |
| Modified Residue | MOD_RES 48; /note=Phosphothreonine; by host; /evidence=ECO:0000250; MOD_RES 184; /note=Phosphothreonine; by host; /evidence=ECO:0000250; MOD_RES 215; /note=Phosphothreonine; by host; /evidence=ECO:0000250; MOD_RES 300; /note=Phosphoserine; by host; /evidence=ECO:0000250; MOD_RES 301; /note=Phosphoserine; by host; /evidence=ECO:0000250 |
| Post Translational Modification | PTM: Phosphorylation at Thr-48 results in the loss of NF-kappa-B activation function. Phosphorylation at Thr-215 results in loss of CREB and NF-B responsive promoters activation. Phosphorylation at Thr-184 has no effect on these Tax functions. Phosphorylation of either Ser-300 or Ser-301 is necessary for localization to nuclear bodies. Thr-48, Thr-184 and Thr-215 are highly phosphorylated, whereas Ser-300 or Ser-301 are only rarely phosphorylated (By similarity). {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 22458338; |
| Motif | MOTIF 73..80; /note=SH3-binding; /evidence=ECO:0000255; MOTIF 188..202; /note=Nuclear export signal; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 37,318 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |