| IED ID | IndEnz0002010030 |
| Enzyme Type ID | protease010030 |
| Protein Name |
Probable Ufm1-specific protease 2 UfSP2 EC 3.4.22.- |
| Gene Name | GA14252 |
| Organism | Drosophila pseudoobscura pseudoobscura (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora obscura group pseudoobscura subgroup Drosophila pseudoobscura Drosophila pseudoobscura pseudoobscura (Fruit fly) |
| Enzyme Sequence | MLPKLKISAFLLKRLERVKQQSSGCLYGVFYGDGTLLLLSFNLSNVGQLNYEQIQHRFPAELDLCGLVKFGDCTDAEAHLNEVIKSVDITDNPILLKCELGTLVGMRASFFVHGKLEEVPYDVMDSEQLYNDFCFTRLQCGFYLQTAATPECVAKEMHVLRKRVADGNLVFKVPHTNIYIHSCGPMDNKLRGESRINDLVQAIPIPSGKENVVADKKKSKTAAQTQLAKHFGATGCEYDLINIDVMRIRTRDLLARDSPPHPALSIAVTTEEQTRAQVPLEIEAMAMLCKNTKLQRLYDVLIESICRALRLFEQSLNEHLAESEGGSLAVPRSHHFYPQGFGHFLSCAYLEGLGDDEPIMQERRKRLHRQFSLPVTRPYFRRANQCHFQGEVDDAPWTPLLNTHVGVRPSAVTDGKEYLVNGNYHYYHYLQQQVQDKGWGCAYRSLQTICSWFVLQGYTNAPIPTHLEVQKYLHKINDKPSSFVGSSQWIGSTEISMCLQGFLKVDSKILHVSSGAELPTIASELAMHFQTQGTPVMIGGGVLAHTIIGVDYCVQSGEVKFLILDPHYTGADELATIQIKGWCGWKSMDFWSKGSYYNLCMPQRPILY |
| Enzyme Length | 608 |
| Uniprot Accession Number | Q2M1D1 |
| Absorption | |
| Active Site | ACT_SITE 441; /evidence=ECO:0000250|UniProtKB:Q99K23; ACT_SITE 565; /evidence=ECO:0000250|UniProtKB:Q99K23; ACT_SITE 567; /evidence=ECO:0000250|UniProtKB:Q99K23 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. {ECO:0000250|UniProtKB:Q99K23, ECO:0000250|UniProtKB:Q9NUQ7}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 68,497 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |