| IED ID |
IndEnz0002010062 |
| Enzyme Type ID |
protease010062 |
| Protein Name |
26S proteasome regulatory subunit rpn12
|
| Gene Name |
rpn12 mts3 SPBC16G5.01 SPBC342.07 |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
Taphrinomycotina
Schizosaccharomycetes
Schizosaccharomycetales
Schizosaccharomycetaceae
Schizosaccharomyces
Schizosaccharomyces pombe (Fission yeast)
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
|
| Enzyme Sequence |
MSTLDLNHLADLYDRKDWNACKKELLKLKVELAKQNLFVPTSDKEKASFARNVFEYGVLVSIQTCDIESFARYASQVIPFYHDSLVPSSRMGLVTGLNLLYLLSENRIAEFHTALESVPDKSLFERDPYVEWVISLEQNVMEGAFDKVASMIRSCNFPEFSYFMKIVMSMVRNEIATCAEKVYSEIPLSNATSLLYLENTKETEKLAEERGWDIRDGVIYFPKEANALETEDGMLIDEEDELELPPTASKHTISSIRQLLSYTSELEQIV |
| Enzyme Length |
270 |
| Uniprot Accession Number |
P50524 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (3); Chain (1); Domain (1); Helix (13) |
| Keywords |
3D-structure;Proteasome;Reference proteome |
| Interact With |
P38937 |
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
4B0Z;
|
| Mapped Pubmed ID |
11058086;
11084332;
12511578;
12553909;
12668659;
16096059;
16149916;
16252005;
18023413;
18062930;
20133687;
20473289;
21091378;
22451489;
22730331;
22906049;
23209828;
23349636;
23697806;
24006256;
25487150;
25720772;
26221037;
27655872;
28366744;
29975113;
32915139;
8918598;
9203581;
9430640;
9653157;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
30,899 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|