| IED ID |
IndEnz0002010063 |
| Enzyme Type ID |
protease010063 |
| Protein Name |
26S proteasome regulatory subunit RPN3
|
| Gene Name |
RPN3 SUN2 YER021W |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Saccharomycotina (true yeasts)
Saccharomycetes
Saccharomycetales
Saccharomycetaceae
Saccharomyces
Saccharomyces cerevisiae (Baker's yeast)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
|
| Enzyme Sequence |
MASTAVMMDVDSSGVNDLHHSEKKYAEEDQVQELLKVLNEISKTTLTLDPRYIWRSLKDLSSLRNQELLNAETLCFTVNVLYPDSSSFKKNLLKFITSNHKSSVPGSAELRNSYPASFYSVNTEKKTIEVTAEINCFMHLLVQLFLWDSKELEQLVEFNRKVVIPNLLCYYNLRSLNLINAKLWFYIYLSHETLARSSEEINSDNQNIILRSTMMKFLKIASLKHDNETKAMLINLILRDFLNNGEVDSASDFISKLEYPHTDVSSSLEARYFFYLSKINAIQLDYSTANEYIIAAIRKAPHNSKSLGFLQQSNKLHCCIQLLMGDIPELSFFHQSNMQKSLLPYYHLTKAVKLGDLKKFTSTITKYKQLLLKDDTYQLCVRLRSNVIKTGIRIISLTYKKISLRDICLKLNLDSEQTVEYMVSRAIRDGVIEAKINHEDGFIETTELLNIYDSEDPQQVFDERIKFANQLHDEYLVSMRYPEDKKTQQNEKSENGENDDDTLDGDLMDDMSDISDLDDLGFL |
| Enzyme Length |
523 |
| Uniprot Accession Number |
P40016 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (5); Chain (1); Compositional bias (2); Domain (1); Helix (19); Initiator methionine (1); Modified residue (2); Region (1); Sequence conflict (2); Turn (2) |
| Keywords |
3D-structure;Acetylation;Direct protein sequencing;Phosphoprotein;Proteasome;Reference proteome |
| Interact With |
Q12250; Q06103 |
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
MOD_RES 2; /note=N-acetylalanine; /evidence=ECO:0000269|PubMed:12504901; MOD_RES 454; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:18407956 |
| Post Translational Modification |
PTM: N-acetylated by NAT1. {ECO:0000269|PubMed:12504901}. |
| Signal Peptide |
|
| Structure 3D |
Electron microscopy (25) |
| Cross Reference PDB |
3J47;
3JCK;
3JCO;
3JCP;
4CR2;
4CR3;
4CR4;
5A5B;
5MPB;
5MPC;
5MPD;
5MPE;
5WVI;
5WVK;
6FVT;
6FVU;
6FVV;
6FVW;
6FVX;
6FVY;
6J2C;
6J2N;
6J2Q;
6J2X;
6J30;
|
| Mapped Pubmed ID |
10323869;
10490625;
10508607;
10664589;
10688190;
11283351;
11742986;
11805826;
11805837;
12827207;
12853471;
14687415;
14759368;
15571806;
15611133;
15905137;
16284124;
16429126;
16554755;
16869714;
16922378;
17499717;
18467557;
18719252;
19446322;
19446323;
19536198;
19683491;
20800707;
21139140;
21543789;
21619884;
21685082;
21966278;
22140548;
22195964;
22237024;
22350874;
22350895;
22956996;
23202731;
23545414;
23643786;
23672618;
23770819;
23911091;
23934994;
24040173;
24412063;
24598877;
24681338;
24706844;
25333764;
26130806;
26182356;
26262643;
26327695;
26365526;
26451487;
26642761;
26744777;
26929360;
27677933;
28106073;
28115689;
30067984;
30792173;
3141402;
8882582;
8982460;
9427841;
9584156;
9697412;
9741626;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
60,393 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|