| IED ID | IndEnz0002010080 |
| Enzyme Type ID | protease010080 |
| Protein Name |
UBX domain-containing protein 1 SAPK substrate protein 1 |
| Gene Name | Ubxn1 Saks1 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLSHILGREPTPSEQVGPEGSGSAAGESKPVLTEEERQEQTKRMLELVAQKQREREEREEREALEREKQRRRQGQELSAARQKLQEDEIRRAAEERRREKAEELAARQRVREKIERDKAERAQKYGGTVGSRSSPPATDPGPVPSSPRQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEEPGQDQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPS |
| Enzyme Length | 297 |
| Uniprot Accession Number | Q499N6 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Coiled coil (1); Compositional bias (1); Domain (2); Initiator methionine (1); Modified residue (6); Region (2) |
| Keywords | Acetylation;Coiled coil;Cytoplasm;Phosphoprotein;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | MOD_RES 2; /note=N-acetylalanine; /evidence=ECO:0000250|UniProtKB:Q04323; MOD_RES 199; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q04323; MOD_RES 200; /note=Phosphoserine; by MAPK12; /evidence=ECO:0000250|UniProtKB:Q04323; MOD_RES 207; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q04323; MOD_RES 229; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q04323; MOD_RES 270; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q04323 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15944415; |
| Motif | |
| Gene Encoded By | |
| Mass | 33,582 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |