| IED ID |
IndEnz0002010112 |
| Enzyme Type ID |
protease010112 |
| Protein Name |
Kunitz-type serine protease inhibitor PIVL
|
| Gene Name |
|
| Organism |
Macrovipera lebetina transmediterranea (Blunt-nosed viper) (Vipera lebetina transmediterranea) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Sauropsida
Sauria (diapsids)
Lepidosauria (lepidosaurs)
Squamata (squamates)
Bifurcata (split-tongued squamates)
Unidentata
Episquamata
Toxicofera
Serpentes (snakes)
Colubroidea
Viperidae
Viperinae (vipers)
Macrovipera
Macrovipera lebetina (Levantine viper) (Vipera lebetina)
Macrovipera lebetina transmediterranea (Blunt-nosed viper) (Vipera lebetina transmediterranea)
|
| Enzyme Sequence |
MSSGGLLLLLGLLTLWAELTPVSSQDRPKFCYLPADPAECNAYMPRFYYDSASNKCKEFIYGGCRGNANNFKNRAECRHTCVASRKGIQPRIASN |
| Enzyme Length |
95 |
| Uniprot Accession Number |
I2G9B4 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Serine protease inhibitor that inhibits trypsin. Exhibits an anti-tumor effect and displays integrin inhibitory activity without being cytotoxic. Is able to dose-dependently inhibit the adhesion, migration and invasion of human glioblastoma U87 cells. Also impairs the function of alphavbeta3 and to a lesser extent, the activity of alphavbeta6, alphavbeta5, alpha1beta1 and alpha5beta1 integrins. {ECO:0000269|PubMed:23262217}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (3); Domain (1); Modified residue (1); Natural variant (1); Propeptide (1); Region (1); Signal peptide (1); Site (1) |
| Keywords |
Disulfide bond;Protease inhibitor;Pyrrolidone carboxylic acid;Secreted;Serine protease inhibitor;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
MOD_RES 25; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:23262217 |
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..24 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
|
| Mass |
10,569 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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