| IED ID |
IndEnz0002010125 |
| Enzyme Type ID |
protease010125 |
| Protein Name |
26S proteasome regulatory subunit rpn10
|
| Gene Name |
rpn10 pus1 SPAC637.10c |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
Taphrinomycotina
Schizosaccharomycetes
Schizosaccharomycetales
Schizosaccharomycetaceae
Schizosaccharomyces
Schizosaccharomyces pombe (Fission yeast)
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
|
| Enzyme Sequence |
MVLEATMILIDNSEWMINGDYIPTRFEAQKDTVHMIFNQKINDNPENMCGLMTIGDNSPQVLSTLTRDYGKFLSAMHDLPVRGNAKFGDGIQIAQLALKHRENKIQRQRIVAFVGSPIVEDEKNLIRLAKRMKKNNVAIDIIHIGELQNESALQHFIDAANSSDSCHLVSIPPSPQLLSDLVNQSPIGQGVVASQNQFEYGVDPNLDVELALALELSMAEERARQEVAAQKSSEETEDKKMQE |
| Enzyme Length |
243 |
| Uniprot Accession Number |
O94444 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation. {ECO:0000269|PubMed:10809753, ECO:0000269|PubMed:12560082}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (7); Chain (1); Domain (2); Helix (7); Region (1) |
| Keywords |
3D-structure;Nucleus;Proteasome;Reference proteome;Ubl conjugation pathway |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10809753}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
2X5N;
|
| Mapped Pubmed ID |
12615927;
16149916;
20473289;
20739285;
22906049;
23173672;
23697806;
25373780;
25720772;
26412298;
29856841;
30726745;
31278118;
33159083;
33260998;
34250083;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
27,140 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|