| IED ID |
IndEnz0002010179 |
| Enzyme Type ID |
protease010179 |
| Protein Name |
Serine protease inhibitor Cvsi-2
|
| Gene Name |
CVSI2 |
| Organism |
Crassostrea virginica (Eastern oyster) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Spiralia
Lophotrochozoa
Mollusca
Bivalvia
Autobranchia
Pteriomorphia
Ostreida
Ostreoidea
Ostreidae (oysters)
Crassostrea
Crassostrea virginica (Eastern oyster)
|
| Enzyme Sequence |
MKVAVVVALLCFVCYTAAETCSADGDCKNTICDASHDLECHRGQCTCVNHATACSSAADCSGSCTIFGRHGRWHCVDAKCRCFFV |
| Enzyme Length |
85 |
| Uniprot Accession Number |
B9A8D7 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Slow-binding inhibitor of serine proteases. The inhibitor rapidly binds to the protease forming a weak enzyme-inhibitor complex, and this is followed by a slow isomerization forming a tight-binding enzyme-inhibitor complex. Active against subtilisin A with a dissociation constant of 0.18 nM. Active against perkinsin. Not active against thermolysin, papain or pepsin. {ECO:0000269|PubMed:19464375}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Signal peptide (1) |
| Keywords |
Direct protein sequencing;Disulfide bond;Protease inhibitor;Secreted;Serine protease inhibitor;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19464375}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Contains 6 disulfide bonds. {ECO:0000305}. |
| Signal Peptide |
SIGNAL 1..18; /evidence=ECO:0000269|PubMed:19464375 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
9,086 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|