| IED ID | IndEnz0002010184 |
| Enzyme Type ID | protease010184 |
| Protein Name |
Secreted phosphoprotein 24 Spp-24 Secreted phosphoprotein 2 |
| Gene Name | SPP2 SPP24 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MISRMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVVKVNSQSLSPYLFRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSWSSSTSESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTDFE |
| Enzyme Length | 211 |
| Uniprot Accession Number | Q13103 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Could coordinate an aspect of bone turnover. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Modified residue (6); Natural variant (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Disulfide bond;Phosphoprotein;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 96; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:24275569; MOD_RES 145; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q62740; MOD_RES 146; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q62740; MOD_RES 170; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q8K1I3; MOD_RES 173; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q8K1I3; MOD_RES 182; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q62740 |
| Post Translational Modification | PTM: Phosphorylation sites are present in the extracellular medium. |
| Signal Peptide | SIGNAL 1..29; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 1435334; 19240061; 19375587; 25339413; 25418420; 25501958; 26091039; 26459573; 27793899; 31849319; 33481052; |
| Motif | |
| Gene Encoded By | |
| Mass | 24,338 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |