| IED ID | IndEnz0002010185 |
| Enzyme Type ID | protease010185 |
| Protein Name |
Signal peptide peptidase-like 2B SPP-like 2B SPPL2b EC 3.4.23.- |
| Gene Name | SPPL2B RCJMB04_29c5 |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MAARWAQFLLFSLLSLPQVYCEYGMVHVLSEKGSSKGKDYCILFNSQWAHLPHDLGKASLLQLQDQTASVLCSPSDVPDGGFNNRIPMVMRGNCTFYEKVRLAQINGARGLLIVSRERLVPPGGNRSQYEEIDIPVALLSYSDMLDIVKSFGRSVKGAMYAPNEPVLDYNMVIIFVMAVGTVAIGGYWAGSRDVKERYMKHKRDDGAEKHEDETVDVTPIMICVFVVMCCSMLVLLYFFYDHLVYVIIGIFCLAASIGLYSCLSPFVRRFPLGKCRIPDNNLPYFHKRPQVRILLLAVFCISVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKGCTLLLLVLFVYDVFFVFITPFLTKTGESIMVEVAAGPSDSATHEKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGIGLLVTFVALALMQMGQPALLYLVPCTLITSFSVALWRKELAMFWTGSGFAKDLPQPPLVIASVNCPQLPKDSNVPASQQETEEMANPTLHVKELHSPTLAAEEPADNDTKTEQSEVSIAQSEEAAGHNKDDLESKSLNLEQKQLE |
| Enzyme Length | 596 |
| Uniprot Accession Number | Q5F383 |
| Absorption | |
| Active Site | ACT_SITE 355; /evidence=ECO:0000250|UniProtKB:P49810; ACT_SITE 417; /evidence=ECO:0000250|UniProtKB:P49810 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250|UniProtKB:Q8TCT7}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (1); Domain (1); Glycosylation (1); Motif (1); Region (1); Signal peptide (1); Topological domain (10); Transmembrane (9) |
| Keywords | Cell membrane;Endosome;Glycoprotein;Golgi apparatus;Hydrolase;Lysosome;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3TD49}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8TCT7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT7}. Lysosome membrane {ECO:0000250|UniProtKB:Q8TCT7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT7}. Endosome membrane {ECO:0000250|UniProtKB:Q8TCT7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT7}. Membrane {ECO:0000250|UniProtKB:Q8TCT7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT7}; Lumenal side {ECO:0000250|UniProtKB:Q8TCT7}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000250|UniProtKB:Q8TCT7 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 468..470; /note=PAL |
| Gene Encoded By | |
| Mass | 66,397 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |