| IED ID | IndEnz0002010284 |
| Enzyme Type ID | protease010284 |
| Protein Name |
Tissue factor TF Coagulation factor III CD antigen CD142 |
| Gene Name | F3 Cf-3 Cf3 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MAILVRPRLLAALAPTFLGCLLLQVIAGAGIPEKAFNLTWISTDFKTILEWQPKPTNYTYTVQISDRSRNWKNKCFSTTDTECDLTDEIVKDVTWAYEAKVLSVPRRNSVHGDGDQLVIHGEEPPFTNAPKFLPYRDTNLGQPVIQQFEQDGRKLNVVVKDSLTLVRKNGTFLTLRQVFGKDLGYIITYRKGSSTGKKTNITNTNEFSIDVEEGVSYCFFVQAMIFSRKTNQNSPGSSTVCTEQWKSFLGETLIIVGAVVLLATIFIILLSISLCKRRKNRAGQKGKNTPSRLA |
| Enzyme Length | 294 |
| Uniprot Accession Number | P20352 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Glycosylation (4); Lipidation (1); Motif (1); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Blood coagulation;Disulfide bond;Glycoprotein;Hemostasis;Lipoprotein;Membrane;Palmitate;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | INDUCTION: Expression in the liver oscillates in a circadian manner. {ECO:0000269|PubMed:23291174}. |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P13726}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P13726}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..28 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10393961; 10438476; 10700190; 10841513; 11154109; 11511099; 11776298; 12244306; 12393670; 12426405; 12579195; 12782720; 1348427; 14576054; 14695325; 15003826; 15073034; 15117736; 15215187; 15280200; 15339841; 15351840; 15475267; 15576370; 15598816; 15613025; 15685171; 15947236; 15956290; 15961065; 15983216; 16020755; 16141072; 16236262; 16385085; 16409465; 16409467; 16602821; 16634773; 16990608; 17234207; 17332247; 17363687; 17371949; 17536017; 17562818; 17663739; 17967980; 18005233; 18055866; 18174463; 18180372; 18231608; 18276908; 18495150; 18599502; 18647222; 18650785; 18763309; 18772494; 18802482; 18931346; 19095643; 19179621; 19234141; 19350121; 19447494; 19535796; 19546589; 19556010; 19620042; 19662362; 19667060; 19712679; 19875693; 19954621; 20008134; 20029945; 20185792; 20303465; 20410508; 20626618; 20671239; 20810696; 20858853; 20861457; 20978007; 21037076; 21042291; 21070799; 21149441; 21262438; 21267068; 21389637; 21496886; 21658367; 21677750; 21717035; 21724997; 22019885; 22192154; 22214850; 22326437; 22407318; 22451716; 22481268; 22547577; 22661702; 22744182; 22837532; 22865892; 22950420; 23038262; 23149844; 23238822; 23305736; 23328933; 23347132; 23487423; 23494077; 24086497; 24520174; 24583261; 24869936; 24879059; 25015658; 25102166; 25116956; 25275013; 25293769; 25339356; 25450387; 25451155; 25476527; 25596265; 25733582; 25884207; 25955268; 26065856; 26325534; 26341257; 26471500; 26817955; 26924425; 27489885; 28028070; 28124089; 28223279; 28350198; 28495929; 28509332; 28724635; 28827327; 28883694; 29419408; 29427323; 29444200; 29483282; 29866044; 30500376; 30602303; 30655274; 31048328; 31262782; 31412737; 31434703; 31836429; 32559654; 33054088; 33498089; 34155039; 7547979; 8113222; 8244375; 8288233; 8291612; 8686734; 8692802; 8779717; 8781413; 8827514; 9192667; 9409643; 9449688; 9537422; 9701458; 9778514; |
| Motif | MOTIF 245..247; /note=WKS motif |
| Gene Encoded By | |
| Mass | 32,935 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |